Metabolic syndrome does not influence the phenotype of LRRK2 and GBA related Parkinson’s disease

• Published in: Scientific reports Vol. 10; no. 1; p. 9329
• Main Authors: Thaler, Avner, Shenhar-Tsarfaty, Shani, Shaked, Yanay, Gurevich, Tanya, Omer, Nurit, Bar-Shira, Anat, Gana-Weisz, Mali, Goldstein, Orly, Kestenbaum, Meir, Cedarbaum, Jesse M., Orr-Urtreger, Avi, Giladi, Nir, Mirelman, Anat
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 09-06-2020; Nature Publishing Group
• Subjects: 631/208; 631/378; Aged; Blood pressure; Cholesterol; Cognitive ability; Female; Genotype & phenotype; Glucosylceramidase - genetics; Glucosylceramidase - metabolism; High density lipoprotein; Humanities and Social Sciences; Humans; Hypertension; Hypertriglyceridemia; Laboratory tests; Leucine-Rich Repeat Serine-Threonine Protein Kinase-2 - genetics; Leucine-Rich Repeat Serine-Threonine Protein Kinase-2 - metabolism; LRRK2 protein; Male; Metabolic disorders; Metabolic syndrome; Metabolic Syndrome - complications; Middle Aged; Movement disorders; multidisciplinary; Mutation; Neurodegenerative diseases; Parkinson Disease - complications; Parkinson Disease - genetics; Parkinson Disease - metabolism; Parkinson's disease; Phenotype; Phenotypes; Probability; Risk; Science; Science (multidisciplinary); Triglycerides
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/s41598-020-66319-9

In order toevaluate the influence of the metabolic syndrome (MS) (obesity, hypertension, elevated triglycerides, reduced levels of HDL cholesterol and glucose impairment) on the phenotype of
LRRK2
and
GBA
Parkinson’s disease (PD), and on the prevalence of prodromal features among individuals at risk, we collected, laboratory test results, blood pressure, demographic, cognitive, motor, olfactory and affective information enabling the assessment of each component of MS and the construction of the MDS prodromal probability score. The number of metabolic components and their levels were compared between participants who were separated based on disease state and genetic status. One hundred and four idiopathic PD, 40
LRRK2
-PD, 70
GBA
-PD, 196 healthy non-carriers, 55
LRRK2
-NMC and 97
GBA
-NMC participated in this study. PD groups and non manifesting carriers (NMC) did not differ in the number of metabolic components (p = 0.101, p = 0.685, respectively).
LRRK2
-PD had higher levels of triglycerides (p = 0.015) and higher rates of prediabetes (p = 0.004), while
LRRK2
-NMC had higher triglyceride levels (p = 0.014). NMC with probability rates for prodromal PD above 50% had higher frequencies of hypertriglyceridemia and prediabetes (p < 0.005, p = 0.023 respectively). While elevated triglycerides and prediabetes were more frequent among
LRRK2
carriers, MS does not seem to influence
GBA
and
LRRK2
-PD phenotype.