Prognostic significance of pretreatment serum lactate dehydrogenase-to-albumin ratio in gastric cancer

• Published in: Contemporary oncology (Poznan, Poland) Vol. 24; no. 3; pp. 145 - 149
• Main Authors: Aday, Ulaş, Tatlı, Faruk, Akpulat, Faik V, İnan, Mazlum, Kafadar, Mehmet T, Bilge, Hüseyin, Başol, Ömer, Oğuz, Abdullah
• Format: Journal Article
• Language: English
• Published: Poland Termedia Publishing House 01-01-2020
• Subjects: curative surgery; gastric cancer; lar; Original Paper; survival; gastric cancer; LAR; curative surgery; survival
• ISSN: 1428-2526; 1897-4309
• DOI: 10.5114/wo.2020.100219

To investigate the prognostic role of lactate dehydrogenase-to-albumin ratio (LAR) in gastric cancer patients undergoing curative resection.
A retrospective study was conducted including resectable gastric cancer patients. According to the time-dependent receiver operating characteristics (ROC) analysis, the optimal threshold for pretreatment LAR was 5.5. The Kaplan-Meier method, Cox regression univariate and multivariate analyses were used to analyze the prognostic factors for disease-free survival and overall survival (OS).
The study cohort consisted of 81 patients, mean age was 60.2 ±13.8 (range, 29-87) years and 55 (67.9%) were male. The median OS time was 34.8 and 45 months in patients with LAR ≥ 5.5 (
= 50) and LAR < 5.5 (
= 31), respectively. Kaplan-Meier curves showed that with the increase in LAR there was reduced survival, but it was not statistically significant (
= 0.278). Multivariate analyses revealed that the positive lymph node ratio above 20% was an independent predictor in resectable gastric cancer patients (OR = 6.281, 95% CI: 1.135-34.767,
= 0.035).
With the increase in LAR survival in gastric cancer decreased, but it was not statistically significant. Studies involving a large patient series are needed.