Association of the NOS3 Gene Polymorphisms with the Risk of Atopic Dermatitis in Children

• Published in: Bulletin of experimental biology and medicine Vol. 170; no. 6; pp. 787 - 790
• Main Authors: Svitich, О. А., Kudryavtseva, А. V., Slyusareva, Е. S., Kravtsova, Е. О., Meremianina, Е. А., Bystritskaya, Е. P., Sobolev, V. V., Ryabtsev, А. I., Potapova, А. B., Zverev, V. V.
• Format: Journal Article
• Language: English
• Published: New York Springer US 01-04-2021; Springer; Springer Nature B.V
• Subjects: Atopic dermatitis; Biomedical and Life Sciences; Biomedicine; Case-Control Studies; Cell Biology; Children; Dermatitis; Dermatitis, Atopic - genetics; Dermatitis, Atopic - metabolism; Development and progression; Diseases; Eczema; Gene Frequency - genetics; Gene polymorphism; Genes; Genetic aspects; Genetic polymorphisms; Genetic Predisposition to Disease - genetics; Genetics; Genotype; Health aspects; Humans; Internal Medicine; Laboratory Medicine; Nitric Oxide Synthase Type III - genetics; NOS3 protein; Pathology; Polymorphism, Single Nucleotide - genetics; Prognosis; Risk factors; atopic dermatitis; gene polymorphism; NO synthase enzyme; NOS3
• ISSN: 0007-4888; 1573-8221
• DOI: 10.1007/s10517-021-05155-x

We studied association of polymorphic markers
Glu298Asp
(
rs1799983
),
C774T
(
rs1549758
), and
T786C
(
rs2070744
) of the
NOS3
gene with the risk of atopic dermatitis. It was found that
T786C
polymorphic marker of the
NOS3
gene is associated with lower risk of erythematosquamous lichenoid atopic dermatitis. A significant association between the homozygous
CC
genotype in locus
786
of the
NOS3
gene and the development of erythematosquamous atopic dermatitis with lichenification was revealed. The homozygous
CC
genotype can be considered as a risk factor of erythematosquamous atopic dermatitis with lichenification.