Integration of Nanoassembly Functions for an Effective Delivery Cascade for Cancer Drugs

A “cluster‐bomb”‐like lipid–dendrimer nanoassembly synergizes the functions of its components and thereby efficiently accomplishes the drug delivery cascade for high efficacy in treating cancer. The nanoassembly successfully circulates in the blood and accumulates in the tumor. Once in the tumor, it...

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Bibliographic Details
Published in:	Advanced materials (Weinheim) Vol. 26; no. 45; pp. 7615 - 7621
Main Authors:	Sun, Qihang, Sun, Xuanrong, Ma, Xinpeng, Zhou, Zhuxian, Jin, Erlei, Zhang, Bo, Shen, Youqing, Van Kirk, Edward A., Murdoch, William J., Lott, Joseph R., Lodge, Timothy P., Radosz, Maciej, Zhao, Yuliang
Format:	Journal Article
Language:	English
Published:	Germany Blackwell Publishing Ltd 03-12-2014
Subjects:	Animals Antineoplastic Agents - administration & dosage biomedical applications Blood Cancer Cascades Cell Line, Tumor Cell Membrane - drug effects Cell Membrane - metabolism Cholesterol - chemistry Clusters Dendrimers Doxorubicin - administration & dosage drug delivery Drug delivery systems Drug Delivery Systems - methods Effectiveness Female Humans lipids Mice Mice, Nude Micelles nanomedicine Nanomedicine - methods Nanostructure Nanostructures - chemistry Neoplasms, Experimental - drug therapy Neoplasms, Experimental - metabolism Phosphatidylethanolamines - chemistry Polyethylene Glycols - chemistry self-assembly Tumors self-assembly nanomedicine lipids drug delivery dendrimers biomedical applications
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Summary:	A “cluster‐bomb”‐like lipid–dendrimer nanoassembly synergizes the functions of its components and thereby efficiently accomplishes the drug delivery cascade for high efficacy in treating cancer. The nanoassembly successfully circulates in the blood and accumulates in the tumor. Once in the tumor, it releases small dendrimers that act like “bomblets”, enabling tumor penetration, cell internalization, and drug release.
Bibliography:	US Department of Defense - No. BC090502 istex:9EB60E2D6732F3235769C5A1D06C179D67BE51B9 Doctoral Fund of Ministry of Education of China - No. 20110101130007 National Natural Science Foundation Key Program - No. 51390481; No. 21090352 National Basic Research Program - No. 2014CB931900 National Fund for Distinguished Young Scholars - No. 50888001 ark:/67375/WNG-M1JXMW3Z-F ArticleID:ADMA201401554 These authors contributed equally to this work. ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0935-9648 1521-4095
DOI:	10.1002/adma.201401554