Multivalent Glycocluster Design through Directed Evolution

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Published in:	Angewandte Chemie International Edition Vol. 50; no. 47; pp. 11238 - 11242
Main Authors:	MacPherson, Iain S., Temme, J. Sebastian, Habeshian, Sevan, Felczak, Krzysztof, Pankiewicz, Krzysztof, Hedstrom, Lizbeth, Krauss, Isaac J.
Format:	Journal Article
Language:	English
Published:	Weinheim WILEY-VCH Verlag 18-11-2011 Wiley Subscription Services, Inc
Edition:	International ed. in English
Subjects:	Antibodies, Monoclonal - chemistry Azides - chemistry Base Sequence Binding Sites carbohydrates cluster effect directed evolution Directed Molecular Evolution - methods DNA - chemistry Drug Design Gene Library glycoconjugates Glycoconjugates - chemical synthesis Glycoconjugates - chemistry Glycosylation HIV Envelope Protein gp120 - chemistry Ligands Mannosides - chemistry Molecular Sequence Data multivalency Protein Binding
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Author	Temme, J. Sebastian MacPherson, Iain S. Pankiewicz, Krzysztof Krauss, Isaac J. Habeshian, Sevan Felczak, Krzysztof Hedstrom, Lizbeth
Author_xml	– sequence: 1 givenname: Iain S. surname: MacPherson fullname: MacPherson, Iain S. organization: Department of Chemistry, Departments of Biology and Chemistry, Brandeis University, 415 South St., Waltham, MA 02454 (USA) – sequence: 2 givenname: J. Sebastian surname: Temme fullname: Temme, J. Sebastian organization: Department of Chemistry, Departments of Biology and Chemistry, Brandeis University, 415 South St., Waltham, MA 02454 (USA) – sequence: 3 givenname: Sevan surname: Habeshian fullname: Habeshian, Sevan organization: Department of Chemistry, Departments of Biology and Chemistry, Brandeis University, 415 South St., Waltham, MA 02454 (USA) – sequence: 4 givenname: Krzysztof surname: Felczak fullname: Felczak, Krzysztof organization: Center for Drug Design, University of Minnesota, 516 Delaware St. SE, MMC 204, Minneapolis, MN 55455 (USA) – sequence: 5 givenname: Krzysztof surname: Pankiewicz fullname: Pankiewicz, Krzysztof organization: Center for Drug Design, University of Minnesota, 516 Delaware St. SE, MMC 204, Minneapolis, MN 55455 (USA) – sequence: 6 givenname: Lizbeth surname: Hedstrom fullname: Hedstrom, Lizbeth organization: Department of Chemistry, Departments of Biology and Chemistry, Brandeis University, 415 South St., Waltham, MA 02454 (USA) – sequence: 7 givenname: Isaac J. surname: Krauss fullname: Krauss, Isaac J. organization: Department of Chemistry, Departments of Biology and Chemistry, Brandeis University, 415 South St., Waltham, MA 02454 (USA)
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/22191092$$D View this record in MEDLINE/PubMed
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Notes	NIH - No. R01 AI090745; No. U01 AI75466-01; No. R01 GM054403 ArticleID:ANIE201105555 ark:/67375/WNG-82MRW5J9-L I.J.K. gratefully acknowledges Brandeis University and the NIH (R01 AI090745). L.H. gratefully acknowledges the NIH (U01 AI75466-01 and R01 GM054403). istex:8FC2D3388666DB69B8121700963D2D3AD8AAA6E9 ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
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SubjectTerms	Antibodies, Monoclonal - chemistry Azides - chemistry Base Sequence Binding Sites carbohydrates cluster effect directed evolution Directed Molecular Evolution - methods DNA - chemistry Drug Design Gene Library glycoconjugates Glycoconjugates - chemical synthesis Glycoconjugates - chemistry Glycosylation HIV Envelope Protein gp120 - chemistry Ligands Mannosides - chemistry Molecular Sequence Data multivalency Protein Binding
Title	Multivalent Glycocluster Design through Directed Evolution
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