LncRNA-Mediated Adipogenesis in Different Adipocytes

Long-chain noncoding RNAs (lncRNAs) are RNAs that do not code for proteins, widely present in eukaryotes. They regulate gene expression at multiple levels through different mechanisms at epigenetic, transcription, translation, and the maturation of mRNA transcripts or regulation of the chromatin str...

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Bibliographic Details
Published in:	International journal of molecular sciences Vol. 23; no. 13; p. 7488
Main Authors:	Zhang, Peiwen, Wu, Shuang, He, Yuxu, Li, Xinrong, Zhu, Yan, Lin, Xutao, Chen, Lei, Zhao, Ye, Niu, Lili, Zhang, Shunhua, Li, Xuewei, Zhu, Li, Shen, Linyuan
Format:	Journal Article
Language:	English
Published:	Basel MDPI AG 05-07-2022 MDPI
Subjects:	Adipocytes Adipogenesis Adipose tissue Apoptosis beige fat Bioaccumulation Body fat brown fat Cancer Cell cycle Chromatin Chronic illnesses Coronaviruses COVID-19 Cytoplasm Diabetes Disease DNA methylation Double-stranded RNA ectopic fat Epigenetics Eukaryotes Fats Gene expression Insulin resistance Lipids Liver long noncoding RNA Mammals Metabolic disorders Metabolism MicroRNAs miRNA Molecular modelling Non-coding RNA Obesity Phosphorylation Proteins Review Signal transduction Tumorigenesis Vitamin deficiency
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Summary:	Long-chain noncoding RNAs (lncRNAs) are RNAs that do not code for proteins, widely present in eukaryotes. They regulate gene expression at multiple levels through different mechanisms at epigenetic, transcription, translation, and the maturation of mRNA transcripts or regulation of the chromatin structure, and compete with microRNAs for binding to endogenous RNA. Adipose tissue is a large and endocrine-rich functional tissue in mammals. Excessive accumulation of white adipose tissue in mammals can cause metabolic diseases. However, unlike white fat, brown and beige fats release energy as heat. In recent years, many lncRNAs associated with adipogenesis have been reported. The molecular mechanisms of how lncRNAs regulate adipogenesis are continually investigated. In this review, we discuss the classification of lncRNAs according to their transcriptional location. lncRNAs that participate in the adipogenesis of white or brown fats are also discussed. The function of lncRNAs as decoy molecules and RNA double-stranded complexes, among other functions, is also discussed.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1 These authors contributed equally to this work.
ISSN:	1422-0067 1661-6596 1422-0067
DOI:	10.3390/ijms23137488