Association of the CYP2B6 gene with anti-tuberculosis drug-induced hepatotoxicity in a Brazilian Amazon population

Highlights • Thirty-one patients out of 220 subjects developed drug-induced hepatotoxicity. • The results for the CYP3A5 gene were not significant among the investigated groups. • The results for the CYP2B6 gene were significant among the investigated groups.

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Bibliographic Details
Published in:	International journal of infectious diseases Vol. 33; no. C; pp. 28 - 31
Main Authors:	Fernandes, Débora Christina Ricardo Oliveira, Santos, Ney Pereira Carneiro, Moraes, Milene Raiol, Braga, Ana Cristina Oliveira, Silva, Cleonardo Augusto, Ribeiro-dos-Santos, Andrea, Santos, Sidney
Format:	Journal Article
Language:	English
Published:	Canada Elsevier Ltd 01-04-2015 Elsevier
Subjects:	Adult Aged Antitubercular Agents - adverse effects Antitubercular Agents - therapeutic use Brazil CYP2B6 CYP3A5 Cytochrome P-450 CYP2B6 - genetics Cytochrome P-450 CYP3A - genetics Female Genotype Hepatotoxicity Humans Infectious Disease Liver - drug effects Male Middle Aged Polymorphism, Single Nucleotide Pulmonary/Respiratory Tuberculosis Tuberculosis - drug therapy Tuberculosis - genetics Brazil Tuberculosis CYP2B6 Hepatotoxicity CYP3A5
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Summary:	Highlights • Thirty-one patients out of 220 subjects developed drug-induced hepatotoxicity. • The results for the CYP3A5 gene were not significant among the investigated groups. • The results for the CYP2B6 gene were significant among the investigated groups.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1201-9712 1878-3511
DOI:	10.1016/j.ijid.2014.04.011