White matter changes and gait decline in cerebral small vessel disease

• Published in: NeuroImage clinical Vol. 17; pp. 731 - 738
• Main Authors: van der Holst, H.M., Tuladhar, A.M., Zerbi, V., van Uden, I.W.M., de Laat, K.F., van Leijsen, E.M.C., Ghafoorian, M., Platel, B., Bergkamp, M.I., van Norden, A.G.W., Norris, D.G., van Dijk, E.J., Kiliaan, A.J., de Leeuw, F.-E.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Inc 01-01-2018; Elsevier
• Subjects: Aged; Aged, 80 and over; Analysis of Variance; Anisotropy; Cerebral small vessel disease (SVD); Cerebral Small Vessel Diseases - complications; Diffusion Tensor Imaging; Diffusion tensor imaging (DTI); Female; Follow-Up Studies; Gait; Gait Disorders, Neurologic - etiology; Gait Disorders, Neurologic - pathology; Humans; Image Processing, Computer-Assisted; Magnetic Resonance Imaging; Male; Middle Aged; MRI; Regular; Severity of Illness Index; Tract-based spatial statistics (TBSS); White Matter - diagnostic imaging; White Matter - physiopathology; Tract-based spatial statistics (TBSS); Gait; MRI; Diffusion tensor imaging (DTI); Cerebral small vessel disease (SVD)
• ISSN: 2213-1582; 2213-1582
• DOI: 10.1016/j.nicl.2017.12.007

The relation between progression of cerebral small vessel disease (SVD) and gait decline is uncertain, and diffusion tensor imaging (DTI) studies on gait decline are lacking. We therefore investigated the longitudinal associations between (micro) structural brain changes and gait decline in SVD using DTI. 275 participants were included from the Radboud University Nijmegen Diffusion tensor and Magnetic resonance imaging Cohort (RUN DMC), a prospective cohort of participants with cerebral small vessel disease aged 50–85years. Gait (using GAITRite) and magnetic resonance imaging measures were assessed during baseline (2006–2007) and follow-up (2011−2012). Linear regression analysis was used to investigate the association between changes in conventional magnetic resonance and diffusion tensor imaging measures and gait decline. Tract-based spatial statistics analysis was used to investigate region-specific associations between changes in white matter integrity and gait decline. 56.2% were male, mean age was 62.9years (SD8.2), mean follow-up duration was 5.4years (SD0.2) and mean gait speed decline was 0.2m/s (SD0.2). Stride length decline was associated with white matter atrophy (β=0.16, p=0.007), and increase in mean white matter radial diffusivity and mean diffusivity, and decrease in mean fractional anisotropy (respectively, β=−0.14, p=0.009; β=−0.12, p=0.018; β=0.10, p=0.049), independent of age, sex, height, follow-up duration and baseline stride length. Tract-based spatial statistics analysis showed significant associations between stride length decline and fractional anisotropy decrease and mean diffusivity increase (primarily explained by radial diffusivity increase) in multiple white matter tracts, with the strongest associations found in the corpus callosum and corona radiata, independent of traditional small vessel disease markers. White matter atrophy and loss of white matter integrity are associated with gait decline in older adults with small vessel disease after 5years of follow-up. These findings suggest that progression of SVD might play an important role in gait decline.
•Relation between progression of small vessel disease and gait decline is uncertain.•We performed longitudinal MRI study in SVD patients.•Reduced WM integrity and volume was significantly related to gait decline.•Progression of SVD is important in gait decline.