Metastasis in renal cell carcinoma: Biology and implications for therapy

Although multiple advances have been made in systemic therapy for renal cell carcinoma (RCC), metastatic RCC remains incurable. In the current review, we focus on the underlying biology of RCC and plausible mechanisms of metastasis. We further outline evolving strategies to combat metastasis through...

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Bibliographic Details
Published in:	Asian Journal of Urology Vol. 3; no. 4; pp. 286 - 292
Main Authors:	Gong, Jun, Maia, Manuel Caitano, Dizman, Nazli, Govindarajan, Ameish, Pal, Sumanta K.
Format:	Journal Article
Language:	English
Published:	Second Military Medical University 01-10-2016 Elsevier
Online Access:	Get full text
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Summary:	Although multiple advances have been made in systemic therapy for renal cell carcinoma (RCC), metastatic RCC remains incurable. In the current review, we focus on the underlying biology of RCC and plausible mechanisms of metastasis. We further outline evolving strategies to combat metastasis through adjuvant therapy. Finally, we discuss clinical patterns of metastasis in RCC and how distinct systemic therapy approaches may be considered based on the anatomic location of metastasis.
Bibliography:	Both authors contributed equally to this work.
ISSN:	2214-3882 2214-3890
DOI:	10.1016/j.ajur.2016.08.006