A Convenient One-Pot Synthesis of Quaternary α-Methoxy- and α-Hydroxycarboxylic Acids
Several α-methoxy- and α-hydroxycarboxylic acids have been synthesized by a new one-pot synthesis using ketones, tribromomethane, and potassium hydroxide in methanol and water, respectively, in good yields.
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| Published in: | Chemical & pharmaceutical bulletin Vol. 47; no. 5; pp. 684 - 686 |
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| Main Authors: | , |
| Format: | Journal Article |
| Language: | English |
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Tokyo
The Pharmaceutical Society of Japan
1999
Maruzen |
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| Abstract | Several α-methoxy- and α-hydroxycarboxylic acids have been synthesized by a new one-pot synthesis using ketones, tribromomethane, and potassium hydroxide in methanol and water, respectively, in good yields. |
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| AbstractList | Several α-methoxy- and α-hydroxycarboxylic acids have been synthesized by a new one-pot synthesis using ketones, tribromomethane, and potassium hydroxide in methanol and water, respectively, in good yields. |
| Author | KUSUMI, Takenori YABUUCHI, Tetsuya |
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| Copyright | The Pharmaceutical Society of Japan 1999 INIST-CNRS |
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| DOI | 10.1248/cpb.47.684 |
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| Discipline | Pharmacy, Therapeutics, & Pharmacology Chemistry |
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| Issue | 5 |
| Keywords | One pot reaction Ether Chiral compound Ketone Bromoform Organic solvent Geminal compound Hydroxyacid Potassium Hydroxides Carboxylic acid Basic medium Aqueous solution Chemical synthesis Methanol |
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| References | 2) Weizmann C., Sulzbacher M., Bergmann E., J. Am. Chem. Soc., 70, 1153-1158 (1948). 3) Mikolajczak K.L., Powell R.G., Smith Jr., C.R., Tetrahedron, 28, 1995-2001 (1972). 4) Weizmann C., Bergmann E., Sulzbacher M., J. Am. Chem. Soc., 70, 1189-1190 (1948). 1) Kusumi T., Takahashi H., Hashimoto T., Kan Y., Asakawa Y., Chemistry Lett., 1994, 1093-1094. |
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| Snippet | Several α-methoxy- and α-hydroxycarboxylic acids have been synthesized by a new one-pot synthesis using ketones, tribromomethane, and potassium hydroxide in... |
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| StartPage | 684 |
| SubjectTerms | Chemistry chiral anisotropic reagent Exact sciences and technology hydroxy acid ketone Organic chemistry α-methoxycarboxylic acid |
| Title | A Convenient One-Pot Synthesis of Quaternary α-Methoxy- and α-Hydroxycarboxylic Acids |
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