A Convenient One-Pot Synthesis of Quaternary α-Methoxy- and α-Hydroxycarboxylic Acids

Several α-methoxy- and α-hydroxycarboxylic acids have been synthesized by a new one-pot synthesis using ketones, tribromomethane, and potassium hydroxide in methanol and water, respectively, in good yields.

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Bibliographic Details
Published in:	Chemical & pharmaceutical bulletin Vol. 47; no. 5; pp. 684 - 686
Main Authors:	YABUUCHI, Tetsuya, KUSUMI, Takenori
Format:	Journal Article
Language:	English
Published:	Tokyo The Pharmaceutical Society of Japan 1999 Maruzen
Subjects:	Chemistry chiral anisotropic reagent Exact sciences and technology hydroxy acid ketone Organic chemistry α-methoxycarboxylic acid One pot reaction Ether Chiral compound Ketone Bromoform Organic solvent Geminal compound Hydroxyacid Potassium Hydroxides Carboxylic acid Basic medium Aqueous solution Chemical synthesis Methanol
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Description
Summary:	Several α-methoxy- and α-hydroxycarboxylic acids have been synthesized by a new one-pot synthesis using ketones, tribromomethane, and potassium hydroxide in methanol and water, respectively, in good yields.
ISSN:	0009-2363 1347-5223
DOI:	10.1248/cpb.47.684