Cine CT for Attenuation Correction in Cardiac PET/CT

• Published in: The Journal of nuclear medicine (1978) Vol. 48; no. 5; pp. 794 - 801
• Main Authors: Alessio, Adam M, Kohlmyer, Steve, Branch, Kelley, Chen, Grace, Caldwell, James, Kinahan, Paul
• Format: Journal Article
• Language: English
• Published: United States Soc Nuclear Med 01-05-2007; Society of Nuclear Medicine
• Subjects: Heart - diagnostic imaging; Humans; Image Enhancement - methods; Medical imaging; Patients; Phantoms, Imaging; Positron-Emission Tomography - instrumentation; Positron-Emission Tomography - methods; Reproducibility of Results; Sensitivity and Specificity; Studies; Tomography, X-Ray Computed - instrumentation; Tomography, X-Ray Computed - methods
• ISSN: 0161-5505; 1535-5667
• DOI: 10.2967/jnumed.106.035717

In dual-modality PET/CT systems, the CT scan provides the attenuation map for PET attenuation correction. The current clinical practice of obtaining a single helical CT scan provides only a snapshot of the respiratory cycle, whereas PET occurs over multiple respiratory cycles. Misalignment of the attenuation map and emission image because of respiratory motion causes errors in the attenuation correction factors and artifacts in the attenuation-corrected PET image. To rectify this problem, we evaluated the use of cine CT, which acquires multiple low-dose CT images during a respiratory cycle. We evaluated the average and the intensity-maximum image of cine CT for cardiac PET attenuation correction.
Cine CT data and cardiac PET data were acquired from a cardiac phantom and from multiple patient studies. The conventional helical CT, cine CT, and PET data of an axially translating phantom were evaluated with and without respiratory motion. For the patient studies, we acquired 2 cine CT studies for each PET acquisition in a rest-stress (13)N-ammonia protocol. Three readers visually evaluated the alignment of 74 attenuation image sets versus the corresponding emission image and determined whether the alignment provided acceptable or unacceptable attenuation-corrected PET images.
In the phantom study, the attenuation correction from helical CT caused a major artifactual defect in the lateral wall on the PET image. The attenuation correction from the average and from the intensity-maximum cine CT images reduced the defect by 20% and 60%, respectively. In the patient studies, 77% of the cases using the average of the cine CT images had acceptable alignment and 88% of the cases using the intensity maximum of the cine CT images had acceptable alignment.
Cine CT offers an alternative to helical CT for compensating for respiratory motion in the attenuation correction of cardiac PET studies. Phantom studies suggest that the average and the intensity maximum of the cine CT images can reduce potential respiration-induced misalignment errors in attenuation correction. Patient studies reveal that cine CT provides acceptable alignment in most cases and suggest that the intensity-maximum cine image offers a more robust alternative to the average cine image.