Fragile X syndrome and autism at the intersection of genetic and neural networks

Autism, an entirely behavioral diagnosis with no largely understood etiologies and no population-wide biomarkers, contrasts with fragile X syndrome (FXS), a single-gene disorder with definite alterations of gene expression and neuronal morphology. Nevertheless, the behavioral overlap between autism...

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Bibliographic Details
Published in:	Nature neuroscience Vol. 9; no. 10; pp. 1221 - 1225
Main Authors:	Belmonte, Matthew K, Bourgeron, Thomas
Format:	Journal Article
Language:	English
Published:	United States Nature Publishing Group 01-10-2006
Subjects:	Animals Autism Autistic Disorder - genetics Autistic Disorder - pathology Fragile X syndrome Fragile X Syndrome - genetics Fragile X Syndrome - pathology Genetic aspects Genetics Humans Models, Biological Nerve Net - pathology Nerve Net - physiopathology Neural circuitry Physiological aspects Risk factors France
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Summary:	Autism, an entirely behavioral diagnosis with no largely understood etiologies and no population-wide biomarkers, contrasts with fragile X syndrome (FXS), a single-gene disorder with definite alterations of gene expression and neuronal morphology. Nevertheless, the behavioral overlap between autism and FXS suggests some overlapping mechanisms. Understanding how the single-gene alteration in FXS plays out within complex genetic and neural network processes may suggest targets for autism research and illustrate strategies for relating autism to more singular genetic syndromes.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1 ObjectType-Feature-1
ISSN:	1097-6256 1546-1726
DOI:	10.1038/nn1765