Neuroprotective approach in acute ischemic stroke: A systematic review of clinical and experimental studies

• Published in: Brain circulation Vol. 8; no. 4; pp. 172 - 179
• Main Authors: Eren, Fettah, Yilmaz, Sueda
• Format: Journal Article
• Language: English
• Published: India Wolters Kluwer India Pvt. Ltd 01-10-2022; Medknow Publications and Media Pvt. Ltd; Medknow Publications & Media Pvt. Ltd; Wolters Kluwer - Medknow; Wolters Kluwer Medknow Publications
• Subjects: clinical trials; Ischemia; ischemic stroke; Medical research; Medicine, Experimental; Nervous system diseases; neuroprotection; neuroprotective agents; preclinical studies; Review; Stroke (Disease); Clinical trials; neuroprotective agents; preclinical studies; neuroprotection; ischemic stroke
• ISSN: 2394-8108; 2455-4626; 2455-4626
• DOI: 10.4103/bc.bc_52_22

Ischemic stroke is a disease with worldwide economic and social negative effects. It is a serious disease with high disability and mortality. Ionic imbalance, excitotoxicity, oxidative stress, and inflammation are induced during and after ischemic stroke. Cellular dysfunction, apoptosis, and necrosis are activated directly or indirectly mechanisms. The studies about neuroprotection in neurodegenerative diseases have increased in recent years. Data about the mechanisms of progressive molecular improvement in the brain tissue are increasing in acute ischemic stroke. Based on these data, preclinical and clinical studies on new neuroprotective treatments are being designed. An effective neuroprotective strategy can prolong the indication period of recanalization treatments in the acute stage of ischemic stroke. In addition, it can reduce neuronal necrosis and protect the brain against ischemia-related reperfusion injury. The current review has evaluated the recent clinical and experimental studies. The molecular mechanism of each of the neuroprotective strategies is also summarized. This review may help develop future strategies for combination treatment to protect the cerebral tissue from ischemia-reperfusion injury.