Registry of Transcatheter Aortic-Valve Implantation in High-Risk Patients

• Published in: The New England journal of medicine Vol. 366; no. 18; pp. 1705 - 1715
• Main Authors: Gilard, Martine, Eltchaninoff, Hélène, Iung, Bernard, Donzeau-Gouge, Patrick, Chevreul, Karine, Fajadet, Jean, Leprince, Pascal, Leguerrier, Alain, Lievre, Michel, Prat, Alain, Teiger, Emmanuel, Lefevre, Thierry, Himbert, Dominique, Tchetche, Didier, Carrié, Didier, Albat, Bernard, Cribier, Alain, Rioufol, Gilles, Sudre, Arnaud, Blanchard, Didier, Collet, Frederic, Santos, Pierre Dos, Meneveau, Nicolas, Tirouvanziam, Ashok, Caussin, Christophe, Guyon, Philippe, Boschat, Jacques, Le Breton, Herve, Collart, Frederic, Houel, Remi, Delpine, Stephane, Souteyrand, Geraud, Favereau, Xavier, Ohlmann, Patrick, Doisy, Vincent, Grollier, Gilles, Gommeaux, Antoine, Claudel, Jean-Philippe, Bourlon, Francois, Bertrand, Bernard, Van Belle, Eric, Laskar, Marc
• Format: Journal Article
• Language: English
• Published: Waltham, MA Massachusetts Medical Society 03-05-2012
• Subjects: Aged; Aged, 80 and over; Aortic stenosis; Aortic Valve Stenosis; Aortic Valve Stenosis - complications; Aortic Valve Stenosis - therapy; Biological and medical sciences; Cardiac Catheterization; Cardiac Catheterization - methods; Cardiology; Female; France; France - epidemiology; General aspects; Geriatrics; Heart Valve Prosthesis; Heart Valve Prosthesis Implantation; Heart Valve Prosthesis Implantation - adverse effects; Heart Valve Prosthesis Implantation - methods; Hemorrhage; Hemorrhage - epidemiology; Hemorrhage - etiology; Human health and pathology; Humans; Incidence; Life Sciences; Male; Medical sciences; Mortality; Multivariate Analysis; Patients; Prospective Studies; Registries; Regurgitation; Risk groups; Stenosis; Stroke; Stroke - epidemiology; Stroke - etiology; Surgery; Tissues and Organs; Transplants & implants; France; Human; Medicine; High risk; Register; Implantation; Patient; Aortic valve
• ISSN: 0028-4793; 1533-4406
• DOI: 10.1056/NEJMoa1114705

Data from a French registry of nearly 3200 transcatheter aortic-valve implantation (TAVI) procedures complement data from randomized clinical trials. This emerging technique shows promise in the treatment of high-risk patients with aortic stenosis.
Aortic stenosis is now the most frequently diagnosed valvular disease.
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,
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Surgical aortic-valve replacement is the definitive therapy for patients with severe symptomatic aortic stenosis.
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,
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Operative mortality is low among selected elderly patients but increases with the number and severity of coexisting illnesses.
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–
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A survey of hospitalized patients revealed the underreferral to surgery of those with severe symptomatic aortic stenosis.
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Transcatheter aortic-valve implantation (TAVI) was developed as an alternative to surgical aortic-valve replacement in this high-risk patient population. Ten years after the first implantation by Cribier and colleagues,
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more than 50,000 patients have been treated by TAVI worldwide. . . .