A new era of GPCR structural and chemical biology

G protein–coupled receptors (GPCRs) are versatile molecular machines that regulate the majority of physiological responses to chemically diverse hormones and neurotransmitters. Recent breakthroughs in structural studies have advanced our understanding of GPCR signaling, particularly the selectivity...

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Bibliographic Details
Published in:	Nature chemical biology Vol. 8; no. 8; pp. 670 - 673
Main Authors:	Granier, Sébastien, Kobilka, Brian
Format:	Journal Article
Language:	English
Published:	New York Nature Publishing Group US 18-07-2012 Nature Publishing Group
Subjects:	631/45/535 631/80/86 631/92/612/194 Animals Biochemical Engineering Biochemistry Bioorganic Chemistry Cell Biology Cell Communication - physiology Cell Membrane - physiology Chemistry Chemistry and Materials Science Chemistry/Food Science commentary Crystallography Drug Discovery Gene Expression Regulation GTP-Binding Proteins - genetics GTP-Binding Proteins - metabolism Hormones Ligands Models, Molecular Molecular biology Neurotransmitters Physiological responses Protein Binding Protein Conformation Protein Folding Protein Stability Proteins Receptors, G-Protein-Coupled - chemistry Receptors, G-Protein-Coupled - classification Receptors, G-Protein-Coupled - physiology Signal Transduction
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Summary:	G protein–coupled receptors (GPCRs) are versatile molecular machines that regulate the majority of physiological responses to chemically diverse hormones and neurotransmitters. Recent breakthroughs in structural studies have advanced our understanding of GPCR signaling, particularly the selectivity of ligand recognition and receptor activation of G proteins.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1552-4450 1552-4469
DOI:	10.1038/nchembio.1025