Chemical and Bioactive Characterization of the Essential Oils Obtained from Three Mediterranean Plants

• Published in: Molecules (Basel, Switzerland) Vol. 26; no. 24; p. 7472
• Main Authors: Xavier, Virginie, Finimundy, Tiane C, Heleno, Sandrina A, Amaral, Joana S, Calhelha, Ricardo C, Vaz, Josiana, Pires, Tânia C S P, Mediavilla, Irene, Esteban, Luis Saúl, Ferreira, Isabel C F R, Barros, Lillian
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 10-12-2021; MDPI
• Subjects: Allelochemicals; Anti-Bacterial Agents - chemistry; Anti-Bacterial Agents - isolation & purification; Anti-Bacterial Agents - pharmacology; Antiinfectives and antibacterials; Antineoplastic Agents, Phytogenic - chemistry; Antineoplastic Agents, Phytogenic - isolation & purification; Antineoplastic Agents, Phytogenic - pharmacology; Antioxidants; Antioxidants - chemistry; Antioxidants - isolation & purification; Antioxidants - pharmacology; Berries; bioactivities; Biocompatibility; Biological activity; Biomass; Biphenyl Compounds - antagonists & inhibitors; Cell Line; Cell Proliferation - drug effects; Cell Survival - drug effects; Chemical composition; Cistus - chemistry; Cupressus - chemistry; Cytotoxicity; Distillation; Drug Screening Assays, Antitumor; Essential oils; Gram-Negative Bacteria - drug effects; Humans; Hydrocarbons; Juniperus - chemistry; Microbial Sensitivity Tests; Minimum inhibitory concentration; Oils & fats; Oils, Volatile - chemistry; Oils, Volatile - isolation & purification; Oils, Volatile - pharmacology; Oxidation; Picrates - antagonists & inhibitors; shrubs; Steam distillation; Tumor cell lines; Tumors; Viridiflorol; Volatile compounds; Volatiles; Spain; essential oils; shrubs; bioactivities
• ISSN: 1420-3049; 1420-3049
• DOI: 10.3390/molecules26247472

L.,
L. and
L. are Mediterranean arboreal and shrub species that possess essential oils (EO) in their leaves and branches. This study aimed at characterizing the EOs obtained by steam distillation from the three species collected in different locations from Spain (Almazán, Andévalo, Barriomartín, Cerezal, Ermitas and Huéscar). For this purpose, volatiles composition was determined by GC-MS, and different bioactivities were evaluated. The highest content in terpenes was observed in
(Huéscar origin) followed by
(Almazán origin), corresponding to 92% and 91.9% of total compounds, respectively. With exception of
from Cerezal that presented viridiflorol as the most abundant compound, all the three species presented in common the α-pinene as the major compound. The EOs from
showed high antibacterial potential, presenting MIC values from 0.3 to 1.25 mg/mL. Concerning other bioactivities,
EO revealed an oxidation inhibition of 83%, while
showed cytotoxicity in the MCF-7 cell line, and
and
EOs exhibited the highest potential on NCI-H460 cell lines. Nevertheless, some EOs revealed toxicity against non-tumoral cells but generally presented a GI
value higher than that of the tumor cell lines.