Maturation of auditory cortex neural responses during infancy and toddlerhood

• Published in: NeuroImage (Orlando, Fla.) Vol. 275; p. 120163
• Main Authors: Chen, Yuhan, Green, Heather L., Putt, Mary E., Allison, Olivia, Kuschner, Emily S., Kim, Mina, Blaskey, Lisa, Mol, Kylie, McNamee, Marybeth, Bloy, Luke, Liu, Song, Huang, Hao, Roberts, Timothy P.L., Edgar, J. Christopher
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 15-07-2023; Elsevier Limited; Elsevier
• Subjects: Acoustic Stimulation; Age; Aged; Auditory; Auditory Cortex - physiology; Auditory system; Babies; Brain research; Convulsions & seizures; Cortex (auditory); Cross-Sectional Studies; Electroencephalography; Evoked Potentials, Auditory - physiology; Gender differences; Hearing; Hemisphere lateralization; Hemispheric laterality; Humans; Infant; Infants; Language; Latency; Localization; Longitudinal studies; Magnetoencephalography; Male; Maturation; Medical screening; MEG; P2m; Sex differences; Hemisphere lateralization; Infant; P2m; Auditory; Language; MEG
• ISSN: 1053-8119; 1095-9572; 1095-9572
• DOI: 10.1016/j.neuroimage.2023.120163

•Nonlinear maturation of auditory cortex neural processes during infancy.•Earlier right than left auditory evoked responses from birth till ∼21 months old.•Hemisphere auditory latency difference associated with language performance.
The infant auditory system rapidly matures across the first years of life, with a primary goal of obtaining ever-more-accurate real-time representations of the external world. Our understanding of how left and right auditory cortex neural processes develop during infancy, however, is meager, with few studies having the statistical power to detect potential hemisphere and sex differences in primary/secondary auditory cortex maturation. Using infant magnetoencephalography (MEG) and a cross-sectional study design, left and right auditory cortex P2m responses to pure tones were examined in 114 typically developing infants and toddlers (66 males, 2 to 24 months). Non-linear maturation of P2m latency was observed, with P2m latencies decreasing rapidly as a function of age during the first year of life, followed by slower changes between 12 and 24 months. Whereas in younger infants auditory tones were encoded more slowly in the left than right hemisphere, similar left and right P2m latencies were observed by ∼21 months of age due to faster maturation rate in the left than right hemisphere. No sex differences in the maturation of the P2m responses were observed. Finally, an earlier left than right hemisphere P2m latency predicted better language performance in older infants (12 to 24 months). Findings indicate the need to consider hemisphere when examining the maturation of auditory cortex neural activity in infants and toddlers and show that the pattern of left–right hemisphere P2m maturation is associated with language performance.