Cutaneous Rosai-Dorfman Disease: Report of a case

• Published in: Indian journal of pathology & microbiology Vol. 56; no. 1; pp. 60 - 61
• Main Authors: Singh, Naorem, Mannan, Abul
• Format: Journal Article
• Language: English
• Published: India Medknow Publications 01-01-2013; Medknow Publications and Media Pvt. Ltd; Wolters Kluwer Medknow Publications
• Subjects: Adult; Biomarkers, Tumor - analysis; Care and treatment; Case studies; Cold; Diagnosis; Health aspects; Histiocytosis; Histiocytosis, Sinus - diagnosis; Histiocytosis, Sinus - pathology; Histocytochemistry; Humans; Immunohistochemistry; Male; Microscopy; Skin Diseases - diagnosis; Skin Diseases - pathology; Thalidomide; India
• ISSN: 0377-4929; 0974-5130
• DOI: 10.4103/0377-4929.116154

A 37-year-old man presented in the surgical outpatient department with one month history of a progressively enlarging painless right neck swelling. On examination, the lesion revealed a 1 x 1 cm reddish nodule on the right posterior triangle of the neck. It was non-tender and freely mobile. There was no associated cervical lymphadenopathy. His other systemic and vital records were noncontributory. The laboratory investigation revealed no significant abnormality. The skin lesion was excised under general anesthesia. In the Pathology Department, we received a small, partially skin covered, well circumscribed nodule, measuring 1 cm in diameter. Cut section was grey-white and firm in consistency. Microscopic examination revealed a well circumscribed dermal lesion [Figure 1]a composed of diffuse sheets of histiocytes with abundant pale cytoplasm admixed with polymorphs, lymphocytes, plasma cells and few scattered eosinophils [Figure 1]b. There was prominent emperipolesis of lymphocytes, polymorphs and plasma cells [Figure 1]c. No atypical cells or epethelioid cell granuloma was seen. Immunological staining showed that the histiocytes were positive for CD68, S-100 protein [Figure 1]d and were negative for CD la and CD20. Thus, a diagnosis of cutaneous Rosai-Dorfman disease was entertained.