Ruthenium porphyrin-induced photodamage in bladder cancer cells

Highlights • Photophysical properties of ruthenium(II) porphyrin, verified that the photosensitizer is capable of activating singlet oxygen. • In vitro experiments on bladder cancer cells, indicated that RuP, irradiated with blue light, induced cellular phototoxicity of 93%. • The present investigat...

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Bibliographic Details
Published in:	Photodiagnosis and photodynamic therapy Vol. 14; pp. 9 - 17
Main Authors:	Bogoeva, Vanya, Siksjø, Monica, Sæterbø, Kristin G, Melø, Thor Bernt, Bjørkøy, Astrid, Lindgren, Mikael, Gederaas, Odrun A
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier B.V 01-06-2016
Subjects:	Animals Bladder cancer Cell Line, Tumor Cell Survival Flow Cytometry Hematology, Oncology and Palliative Medicine Internal Medicine Microscopy, Confocal PDT Photochemotherapy Photodynamic therapy Photophysical characterization Porphyrins - therapeutic use Rats Ruthenium - therapeutic use Ruthenium porphyrin Singlet oxygen Urinary Bladder Neoplasms - therapy Photophysical characterization PDT Photodynamic therapy Singlet oxygen Ruthenium porphyrin Bladder cancer
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Summary:	Highlights • Photophysical properties of ruthenium(II) porphyrin, verified that the photosensitizer is capable of activating singlet oxygen. • In vitro experiments on bladder cancer cells, indicated that RuP, irradiated with blue light, induced cellular phototoxicity of 93%. • The present investigation of RuP-PDT showed that the dominating mode of cell death is necrosis.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1572-1000 1873-1597 1873-1597
DOI:	10.1016/j.pdpdt.2016.01.012