Modeling Disease In Vivo With CRISPR/Cas9

Modeling Disease In Vivo With CRISPR/Cas9

The recent advent of CRISPR/Cas9-mediated genome editing has created a wave of excitement across the scientific research community, carrying the promise of simple and effective genomic manipulation of nearly any cell type. CRISPR has quickly become the preferred tool for genetic manipulation, and sh...

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Bibliographic Details
Published in:Trends in molecular medicine Vol. 21; no. 10; pp. 609 - 621
Main Author: Dow, Lukas E
Format: Journal Article
Language:English
Published: England Elsevier Ltd 01-10-2015
Subjects:
Animals
cancer
Cas9
Clustered Regularly Interspaced Short Palindromic Repeats
CRISPR
CRISPR-Cas Systems
Endonucleases
Humans
in vivo
Models, Biological
Pathology
CRISPR
in vivo
cancer
Cas9
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Summary:The recent advent of CRISPR/Cas9-mediated genome editing has created a wave of excitement across the scientific research community, carrying the promise of simple and effective genomic manipulation of nearly any cell type. CRISPR has quickly become the preferred tool for genetic manipulation, and shows incredible promise as a platform for studying gene function in vivo . I discuss the current application of CRISPR technology to create new in vivo disease models, with a particular focus on how these tools, derived from an adaptive bacterial immune system, are helping us to better model the complexity of human cancer.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Review-1
ISSN:1471-4914
1471-499X
DOI:10.1016/j.molmed.2015.07.006