Evidence That High Catecholamine Levels Produced by Pheochromocytoma May be Responsible for Tako-Tsubo Cardiomyopathy

• Published in: The American journal of cardiology Vol. 115; no. 11; pp. 1615 - 1618
• Main Authors: Sharkey, Scott W., MD, McAllister, Nancy, MD, Dassenko, David, MD, Lin, David, MD, Han, Kelly, MD, Maron, Barry J., MD
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01-06-2015; Elsevier Limited
• Subjects: Adolescent; Age; Aged; Blood pressure; Cardiac arrhythmia; Cardiomyopathy; Cardiovascular; Catecholamines - biosynthesis; Catecholamines - blood; Dopamine; Electrocardiography; Heart attacks; Heart rate; Humans; Hypertension; Hypotheses; Male; Metabolites; NMR; Nuclear magnetic resonance; Ostomy; Pain; Pheochromocytoma - blood; Pheochromocytoma - metabolism; Physiology; Plasma; Takotsubo Cardiomyopathy - blood; Takotsubo Cardiomyopathy - etiology; Tumors; Ultrasonic imaging; Veins & arteries
• ISSN: 0002-9149; 1879-1913
• DOI: 10.1016/j.amjcard.2015.02.069

Tako-tsubo cardiomyopathy (TC) is a novel form of acute heart failure, characterized by regional left ventricular dysfunction without coronary artery obstruction, and usually triggered by a stressful event. Excessive circulating catecholamines have been implicated in the pathophysiology of this condition. This report documents the unusual occurrence of acute TC events in 2 male subjects of disparate ages, 16 and 66 years, for whom subsequent investigation in both led to the unexpected discovery of catecholamine-producing pheochromocytoma. Marked elevation of plasma catecholamines (epinephrine, norepinephrine, and dopamine) was present in both subjects and were remarkably similar to those previously reported in female patients with TC triggered by emotional stress. These observations show a common link between TC occurrence and elevated catecholamine levels in both male and female patients and, therefore, support the hypothesis that excessive levels of catecholamines may be involved in the pathophysiology of TC independent of age or gender.