Effect of Using Triclosan-Impregnated Polyglactin Suture to Prevent Infection of Saphenectomy Wounds in CABG: A Prospective, Double-Blind, Randomized Clinical Trial

• Published in: Revista brasileira de cirurgia cardiovascular Vol. 34; no. 5; pp. 588 - 595
• Main Authors: Santos-Filho, Paulo Samuel, Santos, Marisa, Colafranceschi, Alexandre Siciliano, Pragana, Andrea Nunes de Souza, Correia, Marcelo Goulart, Simões, Heloisa Helena, Rocha, Fernando Alves, Soggia, Maria Eduarda de Vasconcelos, Santos, Ana Paula Malta Samuel, Coutinho, Annie de Azeredo, Figueira, Matheus Swarovsky, Tura, Bernardo Rangel
• Format: Journal Article
• Language: English
• Published: Sao Paulo Sociedade Brasileira de Cirurgia Cardiovascular 01-01-2019
• Subjects: Analgesics; Antibiotics; Body Mass Index; CARDIAC & CARDIOVASCULAR SYSTEMS; Cardiology; Cardiopulmonary Bypass; Cardiovascular disease; Clinical trials; Coronary Artery Bypass Graft; Coronary vessels; Diabetes; Double-blind studies; Erythema; Fever; Heart surgery; Hospitals; Hyperthermia; Infections; Morbidity; Original; Pain; Studies; SURGERY; Sutures; Triclosan; Wound Infection; Brazil; Body Mass Index; Pain; Analgesics; Sutures; Triclosan; Cardiopulmonary Bypass; Erythema; Coronary Artery Bypass Graft; Wound Infection
• ISSN: 1678-9741; 0102-7638; 1678-9741
• DOI: 10.21470/1678-9741-2019-0048

Triclosan (2,4,4'-trichloro-2'-hydroxydiphenyl ether) is an antibacterial substance which, in preclinical studies, has reduced bacterial growth through the inhibition of fatty acid synthesis17. Patients undergoing CABG associated with other cardiac surgeries (valvar surgeries, ventricular aneurysms, acquired ventricular septal defects, congenital heart diseases) or undergoing vascular surgeries other than CABG; bilateral saphenectomized patients; pregnant women; patients under antibiotic therapy for previous infectious disease up to a month before; immunosuppressed patients (acquired immune deficiency syndrome, neoplasia, and or use of corticosteroids > 0.5 mg/kg/day); patients requiring simultaneous carotid artery surgery; and patients with severe peripheral vascular disease, history of venous disease of the deep system and superficial thrombophlebitis of the great saphenous vein, and with psychiatric disorder were excluded from the study. Patient data were obtained from control charts, including demographic (gender and age), clinical (body mass index, diabetes, and analgesic use), and intraoperative (CPB and cross-clamp times) variables and those related to the saphenectomy wounds (pain, dehiscence, erythema, infection, necrosis, and hyperthermia). Thimour-Bergstrom et al.18, investigating triclosan-coated or non-coated sutures to close the saphenectomy wounds of 374 CABG patients, found out that there was a reduction in the infection rate in patients with triclosan sutures in 30-day (clinical visit) and 60-day (telephone interview) follow-ups.