Altered reward processing in patients with lifelong premature ejaculation

• Published in: Scientific reports Vol. 13; no. 1; p. 17539
• Main Authors: Li, Yansong, Li, Xiaojun, Wang, Zixiang, Chen, Xi, Sescousse, Guillaume, Santtila, Pekka, Dai, Yutian, Zhang, Bing
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 16-10-2023; Nature Publishing Group; Nature Portfolio
• Subjects: 631/477; 692/699/2768/515; Ejaculation; Eroticism; Hedonic response; Humanities and Social Sciences; multidisciplinary; Reinforcement; Science; Science (multidisciplinary); Sexual behavior
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/s41598-023-44914-w

Given that sexual behavior is usually pleasurable and highly rewarding, it is surprising that there is as yet no known research to empirically assess how premature ejaculation (PE) patients respond to the rewarding aspect of sexual behavior. This study was designed to address this issue by evaluating how these men respond to the anticipation and hedonic experience of sexual rewards in comparison to non-sexual rewards. Thirty lifelong PE patients and thirty healthy controls (HCs) performed the incentive delay task manipulating both erotic and monetary rewards. Compared to HCs, lifelong PE patients exhibited significantly faster RTs to erotic cues than to monetary cues during reward anticipation. Meanwhile, hedonic experience ratings after obtaining the actual reward showed that erotic rewards were rated as more pleasant than monetary rewards only by lifelong PE patients, which was driven by a decreased sensitivity to experienced monetary rewards in lifelong PE patients compared to HCs. These findings indicate the existence of dysfunctional reward processing in lifelong PE patients, which is characterized by increased incentive motivation elicited by sexual cues and reduced hedonic impact of nonsexual rewards. This study may offer an insightful clue regarding how PE is related to the abnormal regulation of the rewarding aspect of sexual behavior.