Structure-activity correlation of flavonoids for inhibition of bovine lens aldose reductase

To clarify the structure-activity correlation of flavonoids for inhibition of aldose reductase, about fifty flavonoid compounds were screened. The presence of hydrophobic substituents on the A ring and hydrophilic substituents on the B ring of the flavonoid skeleton was suggested to improve the pote...

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Bibliographic Details
Published in:	Chemical & pharmaceutical bulletin Vol. 37; no. 7; pp. 1813 - 1815
Main Authors:	IINUMA, M, TANAKA, T, MIZUNO, M, KATSUZAKI, T, OGAWA, H
Format:	Journal Article
Language:	English
Published:	Tokyo Maruzen 1989
Subjects:	Aldehyde Reductase - antagonists & inhibitors Animals Biological and medical sciences Cattle Digestive system Flavonoids - pharmacology Lens, Crystalline - enzymology Medical sciences Pharmacology. Drug treatments Structure-Activity Relationship Sugar Alcohol Dehydrogenases - antagonists & inhibitors
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Summary:	To clarify the structure-activity correlation of flavonoids for inhibition of aldose reductase, about fifty flavonoid compounds were screened. The presence of hydrophobic substituents on the A ring and hydrophilic substituents on the B ring of the flavonoid skeleton was suggested to improve the potency of inhibitory activity. The activities of extracts of Scutellaria baicalensis, Andrographis paniculata and Gutierrezia microcephala are also described.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0009-2363 1347-5223
DOI:	10.1248/cpb.37.1813