Data in support of substrate flexibility of a mutated acyltransferase domain and implications for polyketide biosynthesis
Enzyme-directed mutasynthesis is an emerging strategy for the targeted derivatization of natural products. Here, data on the synthesis of malonic acid derivatives for feeding studies in Saccharopolyspora erythraea , the mutagenesis of DEBS and bioanalytical data on the experimental investigation of...
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| Published in: | Data in brief Vol. 5; no. C; pp. 528 - 536 |
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| Main Authors: | , , , , , , , , |
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| Abstract | Enzyme-directed mutasynthesis is an emerging strategy for the targeted derivatization of natural products. Here, data on the synthesis of malonic acid derivatives for feeding studies in Saccharopolyspora erythraea , the mutagenesis of DEBS and bioanalytical data on the experimental investigation of studies on the biosynthetic pathway towards erythromycin are presented. |
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| AbstractList | Enzyme-directed mutasynthesis is an emerging strategy for the targeted derivatization of natural products. Here, data on the synthesis of malonic acid derivatives for feeding studies in
Saccharopolyspora erythraea
, the mutagenesis of DEBS and bioanalytical data on the experimental investigation of studies on the biosynthetic pathway towards erythromycin are presented. Enzyme-directed mutasynthesis is an emerging strategy for the targeted derivatization of natural products. Here, data on the synthesis of malonic acid derivatives for feeding studies in Saccharopolyspora erythraea , the mutagenesis of DEBS and bioanalytical data on the experimental investigation of studies on the biosynthetic pathway towards erythromycin are presented. |
| Author | Schulz, Frank Sanchez-Garcia, Elsa Klopries, Stephan Bravo-Rodriguez, Kenny Kushnir, Susanna Sundermann, Uschi Arens, Julia Koopmans, Kyra R.M. Yahiaoui, Samir |
| AuthorAffiliation | d Université de Caen Basse-Normandie, Centre d’Etudes et de Recherche sur le Médicament de Normandie, F-14032 Caen, France a Fakultät für Chemie und Biochemie, Organische Chemie 1, Ruhr-Universität Bochum, Universitätsstraße 150, 44780 Bochum, Germany c Dr. Fooke-Achterrath Laboratorien GmbH, Habichtweg 16, 41468 Neuss, Germany b Max-Planck-Institut für Kohlenforschung, Kaiser-Wilhelm-Platz 1, 45470 Mülheim an der Ruhr, Germany |
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| Author_xml | – sequence: 1 givenname: Stephan surname: Klopries fullname: Klopries, Stephan organization: Fakultät für Chemie und Biochemie, Organische Chemie 1, Ruhr-Universität Bochum, Universitätsstraße 150, 44780 Bochum, Germany – sequence: 2 givenname: Kenny surname: Bravo-Rodriguez fullname: Bravo-Rodriguez, Kenny organization: Max-Planck-Institut für Kohlenforschung, Kaiser-Wilhelm-Platz 1, 45470 Mülheim an der Ruhr, Germany – sequence: 3 givenname: Kyra R.M. surname: Koopmans fullname: Koopmans, Kyra R.M. organization: Fakultät für Chemie und Biochemie, Organische Chemie 1, Ruhr-Universität Bochum, Universitätsstraße 150, 44780 Bochum, Germany – sequence: 4 givenname: Uschi surname: Sundermann fullname: Sundermann, Uschi organization: Dr. Fooke-Achterrath Laboratorien GmbH, Habichtweg 16, 41468 Neuss, Germany – sequence: 5 givenname: Samir surname: Yahiaoui fullname: Yahiaoui, Samir organization: Université de Caen Basse-Normandie, Centre d’Etudes et de Recherche sur le Médicament de Normandie, F-14032 Caen, France – sequence: 6 givenname: Julia surname: Arens fullname: Arens, Julia organization: Fakultät für Chemie und Biochemie, Organische Chemie 1, Ruhr-Universität Bochum, Universitätsstraße 150, 44780 Bochum, Germany – sequence: 7 givenname: Susanna surname: Kushnir fullname: Kushnir, Susanna organization: Fakultät für Chemie und Biochemie, Organische Chemie 1, Ruhr-Universität Bochum, Universitätsstraße 150, 44780 Bochum, Germany – sequence: 8 givenname: Elsa surname: Sanchez-Garcia fullname: Sanchez-Garcia, Elsa organization: Max-Planck-Institut für Kohlenforschung, Kaiser-Wilhelm-Platz 1, 45470 Mülheim an der Ruhr, Germany – sequence: 9 givenname: Frank surname: Schulz fullname: Schulz, Frank email: frank.schulz@rub.de organization: Fakultät für Chemie und Biochemie, Organische Chemie 1, Ruhr-Universität Bochum, Universitätsstraße 150, 44780 Bochum, Germany |
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| References | Koryakina, Williams (bib4) 2011; 12 Hrubowchak, Smith (bib6) 1983; 24 Sundermann, Bravo-Rodriguez, Klopries, Kushnir, Gomez, Sanchez-Garcia (bib1) 2013; 8 Bravo-Rodriguez, Klopries, Koopmans, Sundermann, Yahiaoui, Arens, Kushnir, Schulz, Sanchez-Garcia (bib2) 2015; 22 Singh, Danishefsky (bib5) 1975; 40 Kieser, Buttner, Bibb, Chater, Hopwood (bib8) 2000 Armarego, Chai (bib3) 2009 Kushnir, Sundermann, Yahiaoui, Brockmeyer, Janning, Schulz (bib7) 2012; 51 23106079 - Chembiochem. 2011 Oct 17;12(15):2289-93 23181268 - ACS Chem Biol. 2013 Feb 15;8(2):443-50 26526102 - Chem Biol. 2015 Nov 19;22(11):1425-30 22996590 - Angew Chem Int Ed Engl. 2012 Oct 15;51(42):10664-9 Singh (10.1016/j.dib.2015.09.052_bib5) 1975; 40 Bravo-Rodriguez (10.1016/j.dib.2015.09.052_bib2) 2015; 22 Armarego (10.1016/j.dib.2015.09.052_bib3) 2009 Hrubowchak (10.1016/j.dib.2015.09.052_bib6) 1983; 24 Koryakina (10.1016/j.dib.2015.09.052_bib4) 2011; 12 Sundermann (10.1016/j.dib.2015.09.052_bib1) 2013; 8 Kieser (10.1016/j.dib.2015.09.052_bib8) 2000 Kushnir (10.1016/j.dib.2015.09.052_bib7) 2012; 51 |
| References_xml | – volume: 24 start-page: 4951 year: 1983 end-page: 4954 ident: bib6 article-title: The reductive alkylation of meldrum׳s acid publication-title: Tetrahedron Lett. contributor: fullname: Smith – volume: 40 start-page: 2969 year: 1975 end-page: 2970 ident: bib5 article-title: Preparation of activated cyclopropanes by phase transfer alkylation publication-title: J. Org. Chem. contributor: fullname: Danishefsky – start-page: 88 year: 2009 end-page: 444 ident: bib3 article-title: Purification of organic chemicals publication-title: Purification of Laboratory Chemicals contributor: fullname: Chai – volume: 51 start-page: 10664 year: 2012 end-page: 10669 ident: bib7 article-title: Minimally invasive mutagenesis gives rise to a biosynthetic polyketide library publication-title: Angew. Chem. Int. Ed. contributor: fullname: Schulz – volume: 22 start-page: 1425 year: 2015 end-page: 1430 ident: bib2 article-title: Substrate flexibility of a mutated acyltransferase domain and implications for polyketide biosynthesis publication-title: Chem. Biol. contributor: fullname: Sanchez-Garcia – year: 2000 ident: bib8 article-title: Practical streptomyces genetics contributor: fullname: Hopwood – volume: 8 start-page: 443 year: 2013 end-page: 450 ident: bib1 article-title: Enzyme-directed mutasynthesis: a combined experimental and theoretical approach to substrate recognition of a polyketide synthase publication-title: ACS Chem. Biol. contributor: fullname: Sanchez-Garcia – volume: 12 start-page: 2289 year: 2011 end-page: 2293 ident: bib4 article-title: Mutant malonyl-CoA synthetases with altered specificity for polyketide synthase extender unit generation publication-title: ChemBioChem contributor: fullname: Williams – volume: 12 start-page: 2289 issue: 15 year: 2011 ident: 10.1016/j.dib.2015.09.052_bib4 article-title: Mutant malonyl-CoA synthetases with altered specificity for polyketide synthase extender unit generation publication-title: ChemBioChem doi: 10.1002/cbic.201100383 contributor: fullname: Koryakina – volume: 22 start-page: 1425 issue: 11 year: 2015 ident: 10.1016/j.dib.2015.09.052_bib2 article-title: Substrate flexibility of a mutated acyltransferase domain and implications for polyketide biosynthesis publication-title: Chem. Biol. doi: 10.1016/j.chembiol.2015.02.008 contributor: fullname: Bravo-Rodriguez – volume: 51 start-page: 10664 issue: 42 year: 2012 ident: 10.1016/j.dib.2015.09.052_bib7 article-title: Minimally invasive mutagenesis gives rise to a biosynthetic polyketide library publication-title: Angew. Chem. Int. Ed. doi: 10.1002/anie.201202438 contributor: fullname: Kushnir – year: 2000 ident: 10.1016/j.dib.2015.09.052_bib8 contributor: fullname: Kieser – volume: 8 start-page: 443 issue: 2 year: 2013 ident: 10.1016/j.dib.2015.09.052_bib1 article-title: Enzyme-directed mutasynthesis: a combined experimental and theoretical approach to substrate recognition of a polyketide synthase publication-title: ACS Chem. Biol. doi: 10.1021/cb300505w contributor: fullname: Sundermann – start-page: 88 year: 2009 ident: 10.1016/j.dib.2015.09.052_bib3 article-title: Purification of organic chemicals contributor: fullname: Armarego – volume: 40 start-page: 2969 issue: 20 year: 1975 ident: 10.1016/j.dib.2015.09.052_bib5 article-title: Preparation of activated cyclopropanes by phase transfer alkylation publication-title: J. Org. Chem. doi: 10.1021/jo00908a030 contributor: fullname: Singh – volume: 24 start-page: 4951 issue: 45 year: 1983 ident: 10.1016/j.dib.2015.09.052_bib6 article-title: The reductive alkylation of meldrum׳s acid publication-title: Tetrahedron Lett. doi: 10.1016/S0040-4039(01)99819-3 contributor: fullname: Hrubowchak |
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| Title | Data in support of substrate flexibility of a mutated acyltransferase domain and implications for polyketide biosynthesis |
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