Usual Interstitial Pneumonia Pattern Interstitial Lung Disease Developed in a Patient with IgG4-related Chronic Sclerosing Sialadenitis

• Published in: Internal Medicine Vol. 61; no. 17; pp. 2637 - 2642
• Main Authors: Yamamoto, Hiroshi, Komatsu, Masamichi, Sonehara, Kei, Ikuyama, Yuichi, Urushihata, Kazuhisa, Tateishi, Kazunari, Kitaguchi, Yoshiaki, Ushuiki, Atsuhito, Asaka, Shiho, Uehara, Takeshi, Kawakami, Satoshi, Mori, Kentaro, Hamanaka, Kazutoshi, Nishie, Kenichi, Hebisawa, Akira, Hanaoka, Masayuki
• Format: Journal Article
• Language: English
• Published: Tokyo The Japanese Society of Internal Medicine 01-09-2022; Japan Science and Technology Agency
• Subjects: Biopsy; Case Report; immunoglobulin (Ig) G4; immunoglobulin (Ig) G4-related disease (IgG4-RD); Immunoglobulin G; Immunoglobulins; Internal medicine; interstitial pneumonia; Lung diseases; Patients; Pneumonia; progressive fibrosing; Submandibular gland; usual interstitial pneumonia (UIP)
• ISSN: 0918-2918; 1349-7235
• DOI: 10.2169/internalmedicine.8937-21

A 69-year-old man was diagnosed with immunoglobulin (Ig) G4-related disease (IgG4-RD) at 62 years old. At that time, he had high serum IgG4 levels and bilateral submandibular gland swelling on CT; thus, a gland biopsy was performed. Because a reticular shadow was found on chest CT, a lung surgical biopsy was also performed. The specimens revealed usual interstitial pneumonia (UIP) pattern interstitial pneumonia with some IgG4-positive cells. The patient was subsequently followed up without treatment. His forced vital capacity and radiological findings progressively deteriorated, consistent with UIP pattern interstitial lung disease but different from a lung lesion of IgG4-RD.