Chemosensory control by commissural nucleus of the solitary tract in rats

• Published in: Respiratory physiology & neurobiology Vol. 179; no. 2; pp. 227 - 234
• Main Authors: Favero, Michele T, Takakura, Ana C, de Paula, Patrícia M, Colombari, Eduardo, Menani, José V, Moreira, Thiago S
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier B.V 15-12-2011; Elsevier
• Subjects: Animals; Biological and medical sciences; Blood pressure; Breathing; Carbon dioxide; Cardiovascular system; Central and peripheral chemoreflex; Chemoreception; Chemoreceptor Cells - cytology; Chemoreceptor Cells - drug effects; Chemoreceptor Cells - physiology; Chemoreceptors (internal); Fundamental and applied biological sciences. Psychology; GABA-A Receptor Agonists - pharmacology; Hypercapnia; Hypercapnia - physiopathology; Hypoxia; Hypoxia - physiopathology; Male; Medical Education; Muscimol; Muscimol - pharmacology; Nervous system; NTS; phrenic nerve; Pulmonary/Respiratory; Rats; Rats, Sprague-Dawley; Respiration; Respiratory Physiological Phenomena - drug effects; Sensory neurons; Solitary Nucleus - cytology; Solitary Nucleus - drug effects; Solitary Nucleus - physiology; Solitary tract nucleus; stainless steel; Sympathetic activity; sympathetic nerves; urethane; Ventilation; Vertebrates: respiratory system; Hypoxia; Sympathetic activity; Breathing; NTS; Central and peripheral chemoreflex; Chemoreflex; Oxygen; Rat; Rodentia; Central nervous system; Sympathetic nervous system; Respiratory system; Encephalon; Solitary nucleus; Vertebrata; Mammalia; Autonomic nervous system; Respiration
• ISSN: 1569-9048; 1878-1519
• DOI: 10.1016/j.resp.2011.08.010

Highlights ► We studied cardiorespiratory effects to chemoreflex activation in anesthetized and conscious rats. ► Inhibition of cNTS reduced cardiorespiratory responses elicited by peripheral chemoreflex. ► Inhibition of cNTS did not reduce cardiorespiratory responses elicited by central chemoreflex. ► We suggest that different parts of the NTS are involved with central and peripheral chemoreflexes. ► Caudal portion involved with peripheral chemoreflex and rostral portion with central chemoreflex.