Longitudinal and prospective assessment of prenatal maternal sleep quality and associations with newborn hippocampal and amygdala volume

• Published in: Developmental cognitive neuroscience Vol. 58; p. 101174
• Main Authors: Nevarez-Brewster, Melissa, Demers, Catherine H., Mejia, Alexandra, Haase, Mercedes Hoeflich, Bagonis, Maria M., Kim, Sun Hyung, Gilmore, John H., Hoffman, M. Camille, Styner, Martin A., Hankin, Benjamin L., Davis, Elysia Poggi
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Ltd 01-12-2022; Elsevier
• Subjects: Adult; Amygdala; Amygdala - pathology; Female; Hippocampus; Hippocampus - pathology; Humans; Infant, Newborn; Magnetic Resonance Imaging - methods; Male; MRI; Newborn neurodevelopment; Original Research; Pregnancy; Premature Birth - pathology; Prenatal Exposure Delayed Effects - pathology; Prospective Studies; Sleep; Pregnancy; Newborn neurodevelopment; Sleep; Amygdala; MRI; Hippocampus
• ISSN: 1878-9293; 1878-9307; 1878-9307
• DOI: 10.1016/j.dcn.2022.101174

The rapid maturation of the fetal brain renders the fetus susceptible to prenatal environmental signals. Prenatal maternal sleep quality is known to have important health implications for newborns including risk for preterm birth, however, the effect on the fetal brain is poorly understood.
Participants included 94 pregnant participants and their newborns (53% female). Pregnant participants (Mage = 30; SDage= 5.29) reported on sleep quality three times throughout pregnancy. Newborn hippocampal and amygdala volumes were assessed using structural magnetic resonance imaging. Multilevel modeling was used to test the associations between trajectories of prenatal maternal sleep quality and newborn hippocampal and amygdala volume.
The overall trajectory of prenatal maternal sleep quality was associated with hippocampal volume (left: b = 0.00003, p = 0.013; right: b = 0.00003, p = .008). Follow up analyses assessing timing of exposure indicate that poor sleep quality early in pregnancy was associated with larger hippocampal volume bilaterally (e.g., late gestation left: b = 0.002, p = 0.24; right: b = 0.004, p = .11). Prenatal sleep quality was not associated with amygdala volume.
These findings highlight the implications of poor prenatal maternal sleep quality and its role in contributing to newborn hippocampal development.