Flavonoid glycosides and pharmacological activity of Amphilophium paniculatum

• Published in: Pharmacognosy research Vol. 5; no. 1; pp. 17 - 21
• Main Authors: Nassar, Mahmoud I, Aboutabl, El-Sayed A, Eskander, Dina M, Grace, Mary H, El-Khrisy, Ezzel-Din A, Sleem, Amany A
• Format: Journal Article
• Language: English
• Published: India Medknow Publications and Media Pvt. Ltd 01-01-2013; Phcog.net; Medknow Publications & Media Pvt Ltd
• Subjects: Albinism; Analgesics; Animals; Antioxidants; Drug dosages; Esters; Flavonoids; Glucose; Isoflavones; Laboratories; Mortality; Original; Rodents; Vitamin E; Egypt; Cairo Egypt; Amphilophium paniculatum; flavonoids; bignoniaceae; pharmacology
• ISSN: 0976-4836; 0974-8490; 0974-8490
• DOI: 10.4103/0974-8490.105643

Nothing is reported on Amphilophium paniculatum (L.) Kunth. This study aimed at investigation of chemical constituents of the leaves of Amphilophium paniculatum, grown in Egypt, in addition to pharmacological evaluation.
Isolation of a new compound, along with 5 known flavonoids. Pharmacological activities were carried out on different extracts of A. paniculatum leaves.
Identification of a new flavone glycoside, acacetin 8-C-β-D- glucopyranosy l-(1→2)-α-L-rhamnopyranoside (1) in addition to 5 known flavonoids. The 70% ethanol crud extract and its successive chloroform, ethyl acetate, and 100% ethanol extracts showed significant anti-inflammatoryactivity,analgesic effect, antipyretic activity, antioxidant activity, and anti-hyperglycemic activity. Determination of the median lethal dose (LD50) revealed that the different extracts were safe.