Cerebellar growth, volume and diffusivity in children cooled for neonatal encephalopathy without cerebral palsy

• Published in: Scientific reports Vol. 13; no. 1; pp. 14869 - 11
• Main Authors: Wu, Chelsea Q., Cowan, Frances M., Jary, Sally, Thoresen, Marianne, Chakkarapani, Ela, Spencer, Arthur P. C.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 08-09-2023; Nature Publishing Group; Nature Portfolio
• Subjects: 692/308/3187; 692/617/375/1345/3195; Anisotropy; Asphyxia; Brain - diagnostic imaging; Brain Diseases; Cerebellum; Cerebellum - diagnostic imaging; Cerebral palsy; Cerebral Palsy - diagnostic imaging; Child; Children; Cognitive ability; Developmental disabilities; Encephalopathy; Female; Humanities and Social Sciences; Humans; Infant, Newborn; Infant, Newborn, Diseases; Interpositus nucleus; multidisciplinary; Neonates; Neural networks; Paralysis; Pregnancy; Science; Science (multidisciplinary); Socioeconomics; Substantia alba
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/s41598-023-41838-3

Children cooled for HIE and who did not develop cerebral palsy (CP) still underperform at early school age in motor and cognitive domains and have altered supra-tentorial brain volumes and white matter connectivity. We obtained T1-weighted and diffusion-weighted MRI, motor (MABC-2) and cognitive (WISC-IV) scores from children aged 6–8 years who were cooled for HIE secondary to perinatal asphyxia without CP (cases), and controls matched for age, sex, and socioeconomic status. In 35 case children, we measured cerebellar growth from infancy (age 4–15 days after birth) to childhood. In childhood, cerebellar volumes were measured in 26 cases and 23 controls. Diffusion properties (mean diffusivity, MD and fractional anisotropy, FA) were calculated in 24 cases and 19 controls, in 9 cerebellar regions. Cases with FSIQ ≤ 85 had reduced growth of cerebellar width compared to those with FSIQ > 85 (
p
 = 0.0005). Regional cerebellar volumes were smaller in cases compared to controls (
p
 < 0.05); these differences were not significant when normalised to total brain volume. There were no case–control differences in MD or FA. Interposed nucleus volume was more strongly associated with IQ in cases than in controls (
p
 = 0.0196). Other associations with developmental outcome did not differ between cases and controls.