Posttraumatic stress disorder and pregnancy complications

• Published in: Obstetrics and gynecology (New York. 1953) Vol. 97; no. 1; pp. 17 - 22
• Main Authors: Seng, Julia S, Oakley, Deborah J, Sampselle, Carolyn M, Killion, Cheryl, Graham-Bermann, Sandra, Liberzon, Israel
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 2001; The American College of Obstetricians and Gynecologists; Elsevier Science
• Subjects: Adult; Biological and medical sciences; Diseases of mother, fetus and pregnancy; Female; Gynecology. Andrology. Obstetrics; Humans; Logistic Models; Medical sciences; Odds Ratio; Pregnancy; Pregnancy Complications - etiology; Pregnancy, Ectopic - etiology; Pregnancy. Fetus. Placenta; Stress Disorders, Post-Traumatic - complications; Substance-Related Disorders - complications; Human; Statistical analysis; Posttraumatic syndrome; Pregnancy disorders; Violence; Anxiety disorder; Victimology; Multiple regression; Stress; Logistic regression; Mental disorder; Complication; Female
• ISSN: 0029-7844; 1873-233X
• DOI: 10.1016/S0029-7844(00)01097-8

Objective: To assess the associations between specific pregnancy complications and posttraumatic stress disorder based on neurobiologic and behavioral characteristics, using Michigan Medicaid claims data from 1994–1996.
Methods: Two thousand, two hundred nineteen female recipients of Michigan Medicaid who were of childbearing age had posttraumatic stress disorder on the basis of International Classification of Diseases, 9th Revision (ICD-9) codes. Twenty percent (
n = 455) of those recipients and 30% of randomly selected comparison women with no mental health diagnostic codes (
n = 638;
P < .001) had ICD-9 diagnostic codes for pregnancy complications. We used multiple logistic regression to investigate associations between specific pregnancy complications and posttraumatic stress disorder, controlling for demographic and psychosocial variables. Obstetric complications were hypothesized based on high-risk behaviors and neurobiologic alterations in stress axis function in posttraumatic stress disorder.
Results: After controlling for demographic and psychosocial factors, women with posttraumatic stress disorder had higher odds ratios (ORs) for ectopic pregnancy (OR 1.7, 95% confidence interval [CI] 1.1, 2.8), spontaneous abortion (OR 1.9, 95% CI 1.3, 2.9), hyperemesis (OR 3.9, 95% CI 2.0, 7.4), preterm contractions (OR 1.4, 95% CI 1.1, 1.9), and excessive fetal growth (OR 1.5, 95% CI 1.0, 2.2). Hypothesized labor differences were not confirmed and no differences were found for complications not thought to be related to traumatic stress.
Conclusions: Pregnant women with posttraumatic stress disorder might be at higher risk for certain conditions, and assessment and treatment for undiagnosed posttraumatic stress might be warranted for women with those obstetric complications. Prospective studies are needed to confirm present findings and to determine potential biologic mechanisms. Treatment of traumatic stress symptoms might improve pregnancy morbidity and maternal mental health.