Biological availability and pharmacokinetics of tinidazole after single and repeated doses

• Published in: Scandinavian journal of infectious diseases Vol. 15; no. 4; p. 391
• Main Authors: Vinge, E, Andersson, K E, Ando, G, Lunell, E
• Format: Journal Article
• Language: English
• Published: England 01-12-1983
• Subjects: Adult; Biological Availability; Female; Half-Life; Humans; Kinetics; Male; Middle Aged; Nitroimidazoles - administration & dosage; Time Factors; Tinidazole - administration & dosage; Tinidazole - blood; Tinidazole - urine
• ISSN: 0036-5548
• DOI: 10.3109/inf.1983.15.issue-4.10

Tinidazole was administered to healthy volunteers and serum concentrations were measured following single oral and intravenous doses and after repeated dosage at different dose levels. The elimination half-time was 12-13 h. Pharmacokinetics did not change with dose, route of administration or repeated dosage. The bioavailability of single oral doses ranged between 88 and 129% with a mean of 99%. Serum concentration curves tended to have double peaks or plateaus at about 4-6 h. 74% of the intravenous dose was eliminated from serum at 24 h, but only 19% was recovered in the urine, suggesting alternative ways of elimination. Excretion in the bile and a subsequent enterohepatic circulation may explain the variations in bioavailability and the shape of the serum concentration curves.