Effects of edaravone dexborneol on neurological function and serum inflammatory factor levels in patients with acute anterior circulation large vessel occlusion stroke

• Published in: Translational neuroscience Vol. 14; no. 1; p. 20220312
• Main Authors: Hu, Xiaohong, Qian, Zhenhong, Chen, Jianhui, Chen, Mingsheng, Zhong, Wenying, Shen, Chaoxiong, Hu, Zhizhou, Li, Rongtong
• Format: Journal Article
• Language: English
• Published: Warsaw De Gruyter 12-10-2023; De Gruyter Poland
• Subjects: anterior circulation large vessel occlusion stroke; Circulation; edaravone dexborneol; Hemorrhage; Inflammation; neurological function; Occlusion; Patients; Stroke; thrombectomy
• ISSN: 2081-6936; 2081-3856; 2081-6936
• DOI: 10.1515/tnsci-2022-0312

The goal of this study is to evaluate and analyze the effects of edaravone (EDV) dexborneol on neurological function and serum inflammatory factor levels among patients with acute anterior circulation big artery blockage stroke. A total of 142 patients with acute anterior circulation large vessel occlusion (LVO) were randomly allocated to the study group (69 patients) or the control group (73 patients). In the study group, patients were treated with 37.5 mg EDV dexborneol twice a day for 10–14 days, based on the control group. The primary efficacy outcome was the National Institutes of Health Stroke Scale score change from baseline to 90 days and the proportion of modified Rankin Scale (mRS)score ≤1 at 90 days after randomization. The secondary outcome included the decrease in inflammatory factors at 14 days. The primary safety outcome was the incidence of hemorrhagic transformation assessed according to Heidelberg bleeding classification within 7 days. A higher percentage of patients with HIHSS score ≤5 at 90 days in the EDV dexcamphorol group was observed than in the control group (75.36% vs 64.38%;
= 0.015). A higher percentage of patients with mRS score ≤1 at 90 days in the EDV dexcamphorol group was observed than in the control group (63.77% vs 50.68%;
= 0.012). After treatment, the levels of IL-6 and hs-CRP were significantly lower following treatment and compared to the control group (
< 0.05). In patients receiving the EDV dexborneol group, a significantly decreased risk of radiographic intracranial hemorrhage was found compared with the control group (20.29% vs 39.73%;
= 0.0006). In conclusion, EDV dexborneol can improve the clinical outcomes of patients with acute anterior circulation LVO stroke, which can be used as an effective supplement to thrombectomy therapy.