Tumor-to-tumor spread: a case report and literature review of renal cell carcinoma metastasis into thyroid cancer

• Published in: World journal of surgical oncology Vol. 21; no. 1; pp. 1 - 362
• Main Authors: Gawlik, Cassidy, Lane, Jason, Horattas, Mark
• Format: Journal Article
• Language: English
• Published: London BioMed Central Ltd 22-11-2023; BioMed Central; BMC
• Subjects: Abdomen; Abdominal pain; Cancer; Carcinoma, Renal cell; Care and treatment; Case reports; Causes of; Development and progression; Diagnosis; Family medical history; Hematuria; Kidney cancer; Literature reviews; Lymphatic system; Medical prognosis; Metastases; Metastasis; Mutation; Nodules; Papillary thyroid carcinoma; Pathology; Patients; Prevention; Prognosis; Renal cell carcinoma; Risk factors; Surveillance; Thoracic surgery; Thyroid; Thyroid cancer; Thyroid carcinoma; Thyroid gland; Thyroidectomy; Tumor-to-tumor metastasis; Tumors; Ultrasonic imaging; United States
• ISSN: 1477-7819; 1477-7819
• DOI: 10.1186/s12957-023-03220-5

Tumor-to-tumor metastasis is a rare, yet important entity. Patients with a history of renal cell carcinoma (RCC) may have tumor deposits to the thyroid gland preceding or following their initial cancer diagnosis for many years. The diagnosis can be challenging, and clinicians must remain suspicious of a newly found thyroid nodule in a patient with a history of RCC. In this review, we report a case of a patient with RCC who was incidentally found to have a thyroid nodule on surveillance imaging found to be consistent with tumor-to-tumor metastasis from RCC into papillary thyroid carcinoma. It is imperative to consider this diagnosis as the thyroid is the most common site of spread, and treatment with partial or total thyroidectomy has led to improved survival.