Genetic characterization of Campylobacter jejuni O:41 isolates in relation with Guillain-Barré syndrome

• Published in: Journal of clinical microbiology Vol. 38; no. 2; pp. 874 - 876
• Main Authors: WASSENAAR, T. M, FRY, B. N, LASTOVICA, A. J, WAGENAAR, J. A, COLOE, P. J, DUIM, B
• Format: Journal Article
• Language: English
• Published: Washington, DC American Society for Microbiology 01-02-2000
• Series: Note
• Subjects: Bacteriology; Biological and medical sciences; Campylobacter Infections - microbiology; Campylobacter jejuni; Campylobacter jejuni - classification; Campylobacter jejuni - genetics; Campylobacter jejuni - isolation & purification; Epidemiology; Flagellin; Flagellin - genetics; Fundamental and applied biological sciences. Psychology; Guillain-Barre Syndrome - microbiology; Humans; ID Lelystad, Institute for Animal Science and Health; ID-Lelystad, Instituut voor Dierhouderij en Diergezondheid; Microbiology; Polymerase Chain Reaction; Polymorphism, Restriction Fragment Length; Serotyping; South Africa; South Africa(Republic); Africa; Human; Nervous system diseases; Amplified fragment length polymorphism; Genetic variability; Campylobacteraceae; Flagellin; Genotype; Inflammatory disease; Campylobacter jejuni; Infection; Campylobacter infection; Gene; Bacteriosis; Molecular epidemiology; Bacteria; Peripheral nerve disease; Guillain Barré syndrome
• ISSN: 0095-1137; 1098-660X
• DOI: 10.1128/JCM.38.2.874-876.2000

Campylobacter jejuni O:41 strains are found in association with Guillain-Barré syndrome in South Africa. Strains of this serotype collected over 17 years were characterized by amplified fragment length polymorphism and flagellin typing to determine their clonal nature. Despite minor variation in GM1 expression, all of the strains were genetically indistinguishable, indicating that they are representative of a genetically stable clone.