Risk factors for primary liver carcinoma in Chinese population

• Published in: World journal of gastroenterology : WJG Vol. 11; no. 28; pp. 4431 - 4434
• Main Authors: Luo, Rui-Hong, Zhao, Zhi-Xin, Zhou, Xu-Yu, Gao, Zhi-Liang, Yao, Ji-Lu
• Format: Journal Article
• Language: English
• Published: United States Department of Infectious Diseases, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou 510630, Guangdong Province,China%Medical Information Institute, Sun Yat-Sen University,Guangzhou 510089, Guangdong Province, China 28-07-2005; Baishideng Publishing Group Inc
• Subjects: Alcohol Drinking - epidemiology; Asian Continental Ancestry Group - genetics; Brief Reports; China - epidemiology; Family Health; Food Contamination; Health Behavior; Humans; Liver Neoplasms - ethnology; Risk Factors; 原发性肝癌; 疾病调查; 病毒性肝炎; 肝硬化; China; Primary carcinoma; Liver; Risk factor; Meta-analysis
• ISSN: 1007-9327; 2219-2840
• DOI: 10.3748/wjg.v11.i28.4431

AIM： To evaluate the risk factors for primary liver carcinoma （PLC） in Chinese population.
METHODS： Chinese Biomedical Literature Database, China Hospital Knowledge Database and MEDLINE were searched. All the related literatures were screened, and the risk factors for PLC in Chinese population were studied. Heterogeneity was evaluated by odds ratio （OR） q test. Combined OR and its 95% confidence interval （95%CI）were calculated, the association between the investigated risk factors and PLC was determined. Validity and bias of the findings were evaluated by sensitivity analysis and funnel plot analysis respectively.
RESULTS： Fifty-five of one hundred and ninety identified studies were accepted according to the inclusive criteria. Ten factors related to PLC were demonstrated by sensitive analysis and funnel plot analysis. They were cirrhosis （OR = 11.97, P= 0.000）, HBV infection （OR = 11.34, P= 0.000）,HCV infection （OR = 4.28, P = 0.000）, family history of liver cancer （OR = 3.49, P = 0.000）, unstable emotion （OR = 2.20, P = 0.000）, depressed characters （OR = 3.07,P = 0.000）, aflatoxin （OR = 1.80, P = 0.000）, alcoholic （OR = 1.88, P = 0.000）, intake of musty food （OR =1.87,P = 0.000） and drinking contaminated water from pond （OR = 1.77, P = 0.003）.
CONCLUSION： The main risk factors for PLC in China are liver diseases, family history of liver carcinoma, poor psychic status, aflatoxin, and some unhealthy behaviors.