Rational Chemical Multifunctionalization of Graphene Interface Enhances Targeted Cancer Therapy

• Published in: Angewandte Chemie International Edition Vol. 59; no. 33; pp. 14034 - 14039
• Main Authors: Lucherelli, Matteo Andrea, Yu, Yue, Reina, Giacomo, Abellán, Gonzalo, Miyako, Eijiro, Bianco, Alberto
• Format: Journal Article
• Language: English
• Published: Germany Wiley Subscription Services, Inc 10-08-2020
• Edition: International ed. in English
• Subjects: Anticancer properties; Antineoplastic Agents - administration & dosage; Antineoplastic Agents - chemistry; Antineoplastic Agents - therapeutic use; Antitumor activity; Cancer; Cancer therapies; cancer therapy; carbon materials; Cell Line, Tumor; diazonium salts; Doxorubicin; Drug delivery; Drug Delivery Systems; Folic acid; Graphene; graphite; Graphite - chemistry; Humans; multifunctionalization; Neoplasms - drug therapy; Phototherapy; Synergistic effect; Therapeutic applications; cancer therapy; carbon materials; diazonium salts; multifunctionalization; graphite
• ISSN: 1433-7851; 1521-3773
• DOI: 10.1002/anie.201916112

The synthesis of a drug delivery platform based on graphene was achieved through a step‐by‐step strategy of selective amine deprotection and functionalization. The multifunctional graphene platform, functionalized with indocyanine green, folic acid, and doxorubicin showed an enhanced anticancer activity. The remarkable targeting capacity for cancer cells in combination with the synergistic effect of drug release and photothermal properties prove the great advantage of a combined chemo‐ and phototherapy based on graphene against cancer, opening the doors to future therapeutic applications of this type of material.
Graphene theranostics: A multifunctional drug delivery platform based on graphene, functionalized with indocyanine green, folic acid, and doxorubicin was designed and prepared. The nanoplatform showed an efficient combined chemo‐ and photothermal effect in cancer therapy.