Establishment and validation of a nomogram for predicting overall survival of upper-tract urothelial carcinoma with bone metastasis: a population-based study

• Published in: BMC urology Vol. 24; no. 1; p. 100
• Main Authors: Hu, Jiasheng, Gu, Haowen, Zhang, Dongxu, Wen, Min, Yan, Zejun, Song, Baiyang, Xie, Chengxin
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 30-04-2024; BioMed Central; BMC
• Subjects: Aged; Aged, 80 and over; Analysis; Bone metastasis; Bone Neoplasms - mortality; Bone Neoplasms - secondary; Calibration; Cancer; Cancer therapies; Carcinoma; Carcinoma, Transitional Cell - mortality; Carcinoma, Transitional Cell - secondary; Chemotherapy; Epidemiology; Female; Hospitals; Humans; Kidney Neoplasms - mortality; Kidney Neoplasms - pathology; Male; Marital status; Medical prognosis; Metastases; Metastasis; Middle Aged; Nomograms; Patient outcomes; Patients; Population studies; Prognosis; Radiation therapy; Regression analysis; Retrospective Studies; Risk factors; SEER Program; Software; Statistical analysis; Surgery; Survival Rate; Upper-tract urothelial carcinoma; Ureteral Neoplasms - mortality; Ureteral Neoplasms - pathology; Ureteral Neoplasms - secondary; Urological cancer; Urothelial carcinoma; Bone metastasis; Prognosis; SEER program; Upper-tract urothelial carcinoma; Nomograms
• ISSN: 1471-2490; 1471-2490
• DOI: 10.1186/s12894-024-01488-7

Bone metastasis (BM) carries a poor prognosis for patients with upper-tract urothelial carcinoma (UTUC). This study aims to identify survival predictors and develop a prognostic nomogram for overall survival (OS) in UTUC patients with BM.
The Surveillance, Epidemiology, and End Results database was used to select patients with UTUC between 2010 and 2019. The chi-square test was used to assess the baseline differences between the groups. Kaplan-Meier analysis was employed to assess OS. Univariate and multivariate analyses were conducted to identify prognostic factors for nomogram establishment. An independent cohort was used for external validation of the nomogram. The discrimination and calibration of the nomogram were evaluated using concordance index (C-index), area under receiver operating characteristic curve (AUC), calibration curve, and decision curve analysis (DCA). All statistical analyses were performed using SPSS 23.0 and R software 4.2.2.
The mean OS for UTUC patients with BM was 10 months (95% CI: 8.17 to 11.84), with 6-month OS, 1-year OS, and 3-year OS rates of 41%, 21%, and 3%, respectively. Multi-organ metastases (HR = 2.21, 95% CI: 1.66 to 2.95, P < 0.001), surgery (HR = 0.72, 95% CI: 0.56 to 0.91, P = 0.007), and chemotherapy (HR = 0.37, 95% CI: 0.3 to 0.46, P < 0.001) were identified as independent prognostic factors. The C-index was 0.725 for the training cohort and 0.854 for the validation cohort, and all AUC values were > 0.679. The calibration curve and DCA curve showed the accuracy and practicality of the nomogram.
The OS of UTUC patients with BM was poor. Multi-organ metastases was a risk factor for OS, while surgery and chemotherapy were protective factors. Our nomogram was developed and validated to assist clinicians in evaluating the OS of UTUC patients with BM.