Evaluation and Long-Term Prognosis of New-Onset, Transient, and Persistent Anemia in Ambulatory Patients With Chronic Heart Failure

• Published in: Journal of the American College of Cardiology Vol. 51; no. 5; pp. 569 - 576
• Main Authors: Tang, W.H. Wilson, MD, FACC, Tong, Wilson, MSc, Jain, Anil, MD, Francis, Gary S., MD, FACC, Harris, C. Martin, MD, MBA, Young, James B., MD, FACC
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 05-02-2008; Elsevier Limited
• Subjects: Age Factors; Aged; Analysis of Variance; Anemia; Anemia - complications; Anemia - diagnosis; Anemia - drug therapy; Cardiology; Cardiovascular; Chronic Disease; Clinics; Confidence intervals; Diabetes; Diabetes Complications; Drug therapy; Female; Follow-Up Studies; Heart attacks; Heart failure; Heart Failure - complications; Heart Failure - mortality; Heart Failure - physiopathology; Hemodynamics; Hemoglobins - metabolism; Humans; Internal Medicine; Kaplan-Meier Estimate; Logistic Models; Male; Medical prognosis; Middle Aged; Mortality; Odds Ratio; Prevalence; Prognosis; Proportional Hazards Models; Renal Insufficiency - complications; Risk Factors; Survival analysis; Transplants & implants; Ventricular Function, Left; Womens health; eGFR; MCV; ACE; estimated glomerular filtration rate; BNP; LVEF; hemoglobin; left ventricular ejection fraction; B-type natriuretic peptide; ICD-9; mean corpuscular volume; Hb; International Classification of Diseases-Ninth Revision; angiotensin-converting enzyme
• ISSN: 0735-1097; 1558-3597
• DOI: 10.1016/j.jacc.2007.07.094

Evaluation and Long-Term Prognosis of New-Onset, Transient, and Persistent Anemia in Ambulatory Patients With Chronic Heart Failure W. H. Wilson Tang, Wilson Tong, Anil Jain, Gary S. Francis, C. Martin Harris, James B. Young We reviewed records of 6,159 consecutive ambulatory patients with chronic heart failure followed up at a single center between 2001 and 2006, and found the prevalence of anemia (hemoglobin <12 g/dl for men, <11 g/dl for women) to be 17.2%. At 6-month follow-up, new-onset anemia developed in 16% of patients without prior anemia, whereas 43% patients with anemia at baseline had resolution of their hemoglobin levels. Higher total mortality rates were evident in patients with persistent anemia (58% vs. 31%, p < 0.0001) or with incident anemia (45% vs. 31%, p < 0.0001) compared with those with without anemia at 6 months.