Translocation and extra pulmonary toxicities of multi wall carbon nanotubes in rats

• Published in: Toxicology mechanisms and methods Vol. 20; no. 5; pp. 267 - 272
• Main Authors: Rama Narsimha Reddy, A., Krishna, Devarakonda R., Narsimha Reddy, Y., Himabindu, V.
• Format: Journal Article
• Language: English
• Published: England Informa UK Ltd 01-06-2010; Taylor & Francis
• Subjects: Animals; Carbon nanotubes; Creatinine - blood; Dose-Response Relationship, Drug; extra pulmonary; Heart - drug effects; Kidney - drug effects; Kidney - pathology; Liver - drug effects; Liver - pathology; Lung - drug effects; Male; MWCNT; Nanotubes, Carbon - toxicity; Nanotubes, Carbon - ultrastructure; Rats; Rats, Wistar; toxicity; translocation
• ISSN: 1537-6516; 1537-6524
• DOI: 10.3109/15376516.2010.484077

This study evaluated the ability of the multi wall carbon nanotubes (MWCNT) to induce extra pulmonary toxicities in rats following intra-tracheal (IT) instillation of two MWCNT. Two carbon nanoparticles were instilled into the lungs of rats (0.2, 1, and 5 mg/kg b.w.) and at different post-exposure intervals, blood and organs like liver, kidney, etc. were collected. The histopathological examination of liver tissues revealed a dose-dependent periportal lymphocytic infiltration, ballooning, foamy degeneration, and necrosis at all post-instillation periods. However, examination of kidney revealed the tubular necrosis and interstitial nephritis with 5 mg/kg dose at 1 month of post-instillation of both MWCNT. These liver and kidney toxicities were further confirmed by the elevated levels of respective tissue damage biomarkers. These results suggest the extra pulmonary toxicities of these carbon nanoparticles might be due to the translocation into the liver and kidney.