Cerebral Blood Flow and Metabolism Following Decompressive Craniectomy for Control of Increased Intracranial Pressure

• Published in: Neurosurgery Vol. 67; no. 1; pp. 65 - 72
• Main Authors: Soustiel, Jean F., Sviri, Gill E., Mahamid, Eugenia, Shik, Veniamin, Abeshaus, Sergey, Zaaroor, Menashe
• Format: Journal Article
• Language: English
• Published: United States Oxford University Press 01-07-2010; Wolters Kluwer Health, Inc
• Subjects: Adolescent; Adult; Aged; Aged, 80 and over; Basal Metabolism - physiology; Cerebrovascular Circulation - physiology; Craniotomy - methods; Decompression, Surgical - methods; Energy Metabolism - physiology; Female; Humans; Intracranial Hypertension - metabolism; Intracranial Hypertension - physiopathology; Intracranial Hypertension - surgery; Male; Metabolism; Middle Aged; Mitochondria - metabolism; Prospective Studies; Traumatic brain injury; Young Adult; Cerebral metabolism; Traumatic brain injury; Intracranial pressure; Decompressive craniectomy; Cerebral blood flow
• ISSN: 0148-396X; 1524-4040
• DOI: 10.1227/01.NEU.0000370604.30037.F5

Abstract
OBJECTIVE
Decompressive craniectomy (DC) is a common practice for control of intracranial pressure (ICP) following traumatic brain injury (TBI), although the impact of this procedure on the fate of operated patients is still controversial.
METHODS
Cerebral blood flow (CBF) and metabolic rates were monitored prospectively and daily as a surrogate of neuronal viability in 36 TBI patients treated by DC and compared with those of 86 nonoperated patients. DC was performed either on admission (n = 29) or within 48 hours of admission (n = 7).
RESULTS
DC successfully controlled ICP levels and maintained CBF within a normal range although the cerebral metabolic rate of oxygen (CMRO2) was significantly lower in this group. In 7 patients, pre- and postoperative recordings showed a significant ICP decrease that correlated with CBF augmentation but not with concurrent improvement of CMRO2 that remained particularly low. Logistic regression analysis of all investigated variables showed that DC was not associated with higher mortality despite more severe injuries in this group. However, operated patients were 7-fold more likely to have poor functional outcomes than nonoperated patients. Good functional outcome was strongly associated with higher CMRO2 but not with higher CBF values. CMRO2 levels were significantly lower in the DC group, even after adjustment for injury severity, and showed a progressive and sustained trend of deterioration significantly different from that of the non-DC group.
CONCLUSION
These results suggest that DC may enhance survival in the presence of severe brain swelling, although it is unlikely to represent an adequate answer to mitochondrial damage responsible for cellular energy crisis and edema.