Exploring the potential of telmisartan in chronic constriction injury-induced neuropathic pain in rats

• Published in: European journal of pharmacology Vol. 667; no. 1; pp. 215 - 221
• Main Authors: Jaggi, Amteshwar Singh, Singh, Nirmal
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier B.V 30-09-2011; Elsevier
• Subjects: acetone; Animals; anti-inflammatory activity; Behavior, Animal - drug effects; Benzimidazoles - pharmacology; Benzimidazoles - therapeutic use; Benzoates - pharmacology; Benzoates - therapeutic use; Biological and medical sciences; Chronic constriction injury; cold; Constriction, Pathologic - complications; Cranial nerves. Spinal roots. Peripheral nerves. Autonomic nervous system. Gustation. Olfaction; Female; Foot Deformities - complications; heat; Hyperalgesia - complications; Inflammation; Male; Medical sciences; nerve tissue; Nervous system (semeiology, syndromes); Neuralgia - complications; Neuralgia - drug therapy; Neuralgia - etiology; Neuralgia - metabolism; Neurology; Neuropathic pain; pain; Pharmacology. Drug treatments; Rats; Rats, Wistar; Telmisartan; tumor necrosis factor-alpha; Tumor Necrosis Factor-alpha - metabolism; Inflammation; Chronic constriction injury; Telmisartan; Neuropathic pain; Imidazole derivatives; Nervous system diseases; Rat; Toxicity; Peptide hormone; Rodentia; Octapeptide; Renin angiotensin system; Vertebrata; Chronic; Mammalia; Benzimidazole derivatives; Animal; Antihypertensive agent; Sartan derivatives; Angiotensin antagonist; Lesion; Neuralgia; Angiotensin II; Neurological disorder
• ISSN: 0014-2999; 1879-0712
• DOI: 10.1016/j.ejphar.2011.06.017

The present study was designed to investigate the potential of telmisartan, an angiotensin AT
1 receptor, in chronic constriction injury-induced neuropathic pain in rats. Four loose ligatures were placed around the sciatic nerve to induce chronic constriction injury and neuropathic pain. Acetone drop, pin-prick, hot plate and paint brush tests were performed to assess cold allodynia; mechanical and heat hyperalgesia; and dynamic mechanical allodynia, respectively along with assessment of spontaneous pain and postural index in terms of foot deformity. The levels of TNF-α were measured in the sciatic nerve as an index of inflammation. Chronic constriction injury was associated with development of cold allodynia; mechanical and heat hyperalgesia; dynamic mechanical allodynia; and spontaneous pain and foot deformity along with rise in the levels of TNF-α. Telmisartan (1, 2, 5
mg/kg,
p.o.) was administered for 14
days in chronic constriction injury subjected rats. Administration of telmisartan (2, 5
mg/kg) significantly attenuated chronic constriction injury-induced pain related behavior, foot deformity and rise in TNF-α level. It may be concluded that telmisartan has a potential in attenuating neuropathic pain behavior in chronic constriction injury model which may possibly be attributed to its anti-inflammatory properties.