Severe and Persistent Thyroid Dysfunction Associated with Tetracycline-Antibiotic Treatment in Youth

• Published in: The Journal of pediatrics Vol. 173; pp. 232 - 234
• Main Authors: Pollock, Allison J., MD, Seibert, Tasa, MD, MPH, Allen, David B., MD
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01-06-2016
• Subjects: acne vulgaris; Acne Vulgaris - drug therapy; Adolescent; Anti-Bacterial Agents - adverse effects; Diplopia - etiology; doxycycline; Fatigue - etiology; Female; Headache - etiology; Humans; hyperthyroidism; Hyperthyroidism - chemically induced; Hyperthyroidism - diagnosis; hypothyroidism; Male; minocycline; Minocycline - adverse effects; Pediatrics; Polydipsia - etiology; tetracycline; thyroid dysfunction; thyroiditis; Thyrotropin - blood; Thyroxine - blood; Weight Loss; hypothyroidism; TSH; Thyroid stimulating hormone; Thyroid stimulating immunoglobulin; TSI; doxycycline; Free T4; acne vulgaris; TPO; hyperthyroidism; Thyroid peroxidase; minocycline; thyroiditis; tetracycline; thyroid dysfunction; Free thyroxine
• ISSN: 0022-3476; 1097-6833
• DOI: 10.1016/j.jpeds.2016.03.034

Thyroid dysfunction in adolescents treated with minocycline for acne has been previously described as transient effect and/or associated with autoimmune thyroiditis. We report nonimmune-mediated thyroid dysfunction associated with minocycline/doxycycline in 3 adolescents whose clinical courses suggest an adverse effect that may be more common, serious, and persistent than realized previously.