Overview of Nrf2 as Therapeutic Target in Epilepsy

• Published in: International journal of molecular sciences Vol. 16; no. 8; pp. 18348 - 18367
• Main Authors: Carmona-Aparicio, Liliana, Pérez-Cruz, Claudia, Zavala-Tecuapetla, Cecilia, Granados-Rojas, Leticia, Rivera-Espinosa, Liliana, Montesinos-Correa, Hortencia, Hernández-Damián, Jacqueline, Pedraza-Chaverri, José, Sampieri, 3rd, Aristides, Coballase-Urrutia, Elvia, Cárdenas-Rodríguez, Noemí
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 07-08-2015; MDPI
• Subjects: Animals; Epilepsy; Epilepsy - drug therapy; Epilepsy - metabolism; Humans; Molecular Targeted Therapy - methods; NF-E2-Related Factor 2 - chemistry; NF-E2-Related Factor 2 - metabolism; Nitrogen; Nrf2; Oxidative Stress; Oxygen; Review; Signal Transduction; stress oxidative; transcription factor nuclear; epilepsy; transcription factor nuclear; stress oxidative; Nrf2
• ISSN: 1422-0067; 1661-6596; 1422-0067
• DOI: 10.3390/ijms160818348

Oxidative stress is a biochemical state of imbalance in the production of reactive oxygen and nitrogen species and antioxidant defenses. It is involved in the physiopathology of degenerative and chronic neuronal disorders, such as epilepsy. Experimental evidence in humans and animals support the involvement of oxidative stress before and after seizures. In the past few years, research has increasingly focused on the molecular pathways of this process, such as that involving transcription factor nuclear factor E2-related factor 2 (Nrf2), which plays a central role in the regulation of antioxidant response elements (ARE) and modulates cellular redox status. The aim of this review is to present experimental evidence on the role of Nrf2 in this neurological disorder and to further determine the therapeutic impact of Nrf2 in epilepsy.