Weight loss surgery improves quality of life in pediatric patients with osteogenesis imperfecta

• Published in: Surgery for obesity and related diseases Vol. 13; no. 1; pp. 41 - 44
• Main Authors: Zani, Augusto, M.D., Ph.D, Ford-Adams, Martha, M.R.C.P., F.R.C.P.Ch, Ratcliff, Megan, Ph.D, Bevan, Denise, D.Clin.Psy, Inge, Thomas H., M.D., Ph.D., F.A.C.S., F.A.A.P, Desai, Ashish, M.Ch., F.R.C.S. (Paeds)
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01-01-2017
• Subjects: Activities of Daily Living; Adolescent; Bariatric Surgery - psychology; Body Mass Index; Brittle bone; Child; Female; Gastrectomy - psychology; Gastroenterology and Hepatology; Humans; Laparoscopic; Laparoscopy - psychology; Male; Obesity; Obesity, Morbid - psychology; Obesity, Morbid - surgery; Osteogenesis imperfecta; Osteogenesis Imperfecta - psychology; Pediatric; Pediatric Obesity - psychology; Pediatric Obesity - surgery; Postoperative Care; Quality of Life; Sleeve gastrectomy; Surgery; Treatment Outcome; Weight loss surgery; Weight Reduction Programs - methods; Obesity; Osteogenesis imperfecta; Brittle bone; Weight loss surgery; Laparoscopic; Child; Pediatric; Quality of life; Sleeve gastrectomy
• ISSN: 1550-7289; 1878-7533
• DOI: 10.1016/j.soard.2015.11.029

Abstract Background Osteogenesis imperfecta (OI) is an inherited disorder, which causes brittle bones resulting in recurrent fractures. The associated poor mobility of children with OI increases susceptibility to obesity, and obesity further dramatically limits mobility and increases fracture risk. Objectives The aim of this report is to describe outcomes of weight loss surgery (WLS) in 2 adolescents with severe obesity and OI. Setting Two University Hospitals (in the United Kingdom and in the United States). Methods Two cases of OI treated with WLS were identified. Pre- and postoperative anthropometric and biochemical data and clinical course were reviewed. Results In these 2 cases, preoperative Body Mass Index (BMI) values were 38 and 46 kg/m2 . Following laparoscopic sleeve gastrectomy (LSG), BMI decreased by 55% and 60% by 26 and 24 months, respectively. There were no surgical complications, and both patients experienced improvement in their mobility and ability to perform activities of daily living. Conclusion WLS effectively treated severe obesity in 2 OI patients and substantially improved mobility and quality of life, theoretically reducing fracture risk.