Setting the Trajectory: Racial Disparities in Newborn Telomere Length

• Published in: The Journal of pediatrics Vol. 166; no. 5; pp. 1181 - 1186
• Main Authors: Drury, Stacy S., MD, PhD, Esteves, Kyle, BS, Hatch, Virginia, BS, Woodbury, Margaret, BS, Borne, Sophie, Adamski, Alys, MPH, Theall, Katherine P., PhD
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01-05-2015
• Subjects: Adolescent; Adult; Black or African American; Black People; Dried Blood Spot Testing - methods; Ethnicity; Female; Health Status Disparities; Humans; Infant, Newborn; Male; Neonatal Screening - methods; New Orleans; Pediatrics; Pregnancy; Real-Time Polymerase Chain Reaction; Sequence Analysis, DNA; Sex Factors; Telomere - ultrastructure; White People; New Orleans; Polymerase chain reaction; CV; Coefficients of variations; TL; Telomere to single copy; T/S; Telomere length; PCR
• ISSN: 0022-3476; 1097-6833
• DOI: 10.1016/j.jpeds.2015.01.003

Objective To explore racial differences in newborn telomere length (TL) and the effect moderation of the sex of the infant while establishing the methodology for the use of newborn blood spots for TL analyses. Study design Pregnant mothers were recruited from the Greater New Orleans area. TL was determined via monochrome multiplex quantitative real-time polymerase chain reaction on DNA extracted from infant blood spots. Demographic data and other covariates were obtained via maternal report before the infant's birth. Birth outcome data were obtained from medical records and maternal report. Results Black infants weighed significantly less than white infants at birth and had significantly longer TL than white infants ( P  = .0134), with the strongest effect observed in black female infants. No significant differences in gestational age were present. Conclusions Significant racial differences in TL were present at birth in this sample, even after we controlled for a range of birth outcomes and demographic factors. Because longer initial TL is predictive of more rapid TL attrition across the life course, these findings provide evidence that, even at birth, biological vulnerability to early life stress may differ by race and sex.