RNAi-Based Therapy: Combating Shrimp Viral Diseases

• Published in: Viruses Vol. 15; no. 10; p. 2050
• Main Authors: Alam, Md. Shahanoor, Islam, Mohammad Nazrul, Das, Mousumi, Islam, Sk. Farzana, Rabbane, Md. Golam, Karim, Ehsanul, Roy, Animesh, Alam, Mohammad Shafiqul, Ahmed, Raju, Kibria, Abu Syed Md
• Format: Journal Article
• Language: English
• Published: Basel MDPI AG 01-10-2023; MDPI
• Subjects: Apoptosis; Aquaculture; Care and treatment; Disease; dsRNA; Fever; Gene silencing; Hyperthermia; Immune system; Infections; innate immune response; Mortality; Pathogens; penaeid shrimp; Review; RNA-mediated interference; Seafood; shrimp viral diseases; Shrimps; siRNA; therapeutics; Vaccines; Viral diseases; Viral infections; Virus diseases; Viruses; Water temperature; Bangladesh
• ISSN: 1999-4915; 1999-4915
• DOI: 10.3390/v15102050

Shrimp aquaculture has become a vital industry, meeting the growing global demand for seafood. Shrimp viral diseases have posed significant challenges to the aquaculture industry, causing major economic losses worldwide. Conventional treatment methods have proven to be ineffective in controlling these diseases. However, recent advances in RNA interference (RNAi) technology have opened new possibilities for combating shrimp viral diseases. This cutting-edge technology uses cellular machinery to silence specific viral genes, preventing viral replication and spread. Numerous studies have shown the effectiveness of RNAi-based therapies in various model organisms, paving the way for their use in shrimp health. By precisely targeting viral pathogens, RNAi has the potential to provide a sustainable and environmentally friendly solution to combat viral diseases in shrimp aquaculture. This review paper provides an overview of RNAi-based therapy and its potential as a game-changer for shrimp viral diseases. We discuss the principles of RNAi, its application in combating viral infections, and the current progress made in RNAi-based therapy for shrimp viral diseases. We also address the challenges and prospects of this innovative approach.