Correlation of cognitive and masticatory function in Alzheimer’s disease

• Published in: Clinical oral investigations Vol. 21; no. 2; pp. 573 - 578
• Main Authors: Campos, Camila Heitor, Ribeiro, Giselle Rodrigues, Costa, José Luiz Riani, Rodrigues Garcia, Renata Cunha Matheus
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01-03-2017; Springer Nature B.V
• Subjects: Aged; Alzheimer Disease - physiopathology; Alzheimer's disease; Case-Control Studies; Cross-Sectional Studies; Dentistry; Female; Humans; Jaw, Edentulous - physiopathology; Jaw, Edentulous, Partially - physiopathology; Male; Mastication - physiology; Medicine; Original Article; Alzheimer’s disease; Mastication; Cognition
• ISSN: 1432-6981; 1436-3771
• DOI: 10.1007/s00784-016-1923-z

Objectives
This study investigated chewing function in elderly individuals with Alzheimer’s disease (AD) and correlated chewing function with cognitive status.
Materials and methods
Sixteen elderly individuals with mild AD (mean age 76.7 ± 6.3 years; 8 men, 8 women) and 16 age and gender-matched healthy controls (mean age 75.23 ± 4.4 years; 8 men, 8 women) were included in this study. All volunteers wore removable prostheses: 11 were totally edentulous and five were partially edentulous in each group. Chewing function was evaluated via masticatory performance (MP) using Optocal chewable test material and a sieve fractionation method. Cognitive functioning was assessed by the Mini Mental State Exam (MMSE), administered by a trained examiner. Data were analyzed by non-paired
t
test and Pearson’s correlation with
α
 = 0.05.
Results
Compared to controls, mild AD patients had decreased MP (
P
 < 0.01) and MMSE (
P
 = 0.01). MP showed a moderate negative correlation with MMSE (
r
 = −0.69).
Conclusions
Mild AD was associated with impaired chewing function.
Clinical relevance
Knowledge that mild AD has an impact on chewing is important for dental professionals in decision-making related to prosthetics and general dental treatment.