Cutaneous wart-associated HPV types: Prevalence and relation with patient characteristics

• Published in: Journal of clinical virology Vol. 55; no. 3; pp. 250 - 255
• Main Authors: Bruggink, Sjoerd C, de Koning, Maurits N.C, Gussekloo, Jacobijn, Egberts, Paulette F, ter Schegget, Jan, Feltkamp, Mariet C.W, Bavinck, Jan Nico Bouwes, Quint, Wim G.V, Assendelft, Willem J.J, Eekhof, Just A.H
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier B.V 01-11-2012; Elsevier
• Subjects: Adolescent; Adult; Aged; Allergy and Immunology; Biological and medical sciences; Child; Child, Preschool; Children; Cutaneous warts; Data processing; DNA; Epidemiology; Female; Fundamental and applied biological sciences. Psychology; Genotype; Human papillomavirus; Human papillomavirus (HPV); Human viral diseases; Humans; Infectious Disease; Infectious diseases; Male; Medical sciences; Microbiology; Middle Aged; Miscellaneous; Papillomaviridae - classification; Papillomaviridae - genetics; Papillomaviridae - isolation & purification; Papillomavirus Infections - epidemiology; Papillomavirus Infections - virology; Patient characteristics; Prevalence; Skin Diseases, Viral - epidemiology; Skin Diseases, Viral - virology; Viral diseases; Viral diseases with cutaneous or mucosal lesions and viral diseases of the eye; Virology; Warts; Warts - epidemiology; Warts - virology; Young Adult; HSL; hyperkeratotic skin lesion; Prevalence; CI; Epidemiology; HPV; Patient characteristics; Cutaneous warts; PCR/MPG; human papillomavirus; polymerase chain reaction/multiplex genotyping; confidence interval; Human papillomavirus (HPV); Human; Skin disease; Keywords; Wart; Papovaviridae; Infection; Papillomavirus; Virus; Human papillomavirus; Viral disease
• ISSN: 1386-6532; 1873-5967
• DOI: 10.1016/j.jcv.2012.07.014

Abstract Background Epidemiological data on cutaneous wart-associated HPV types are rare. Objectives To examine the prevalence of cutaneous wart-associated HPV types and their relation with patient characteristics. Study design Swabs were taken from all 744 warts of 246 consecutive immunocompetent participants and analysed by a broad spectrum HSL-PCR/MPG assay. Patient details including location, duration, and number of warts were recorded. Results No HPV DNA was detected in 49 (7%) swabs, a single HPV type in 577 (78%) swabs, and multiple HPV types in 118 (16%) swabs. HPV 2, 27 and 57 (alpha genus), HPV 4 (gamma genus) and HPV 1 (mu genus) were the most frequently detected HPV types, and HPV 63 (mu genus) was only frequently detected together with other HPV types. Less frequently detected HPV types were HPV 3, 7, 10 and 28 (alpha genus), 65, 88 and 95 (gamma genus) and 41 (nu genus). Warts containing HPV 1 showed the most distinct clinical profile, being related to children aged <12 years, plantar location, duration <6 months, and to patients with <4 warts. Conclusions HPV 27, 57, 2 and 1 are the most prevalent HPV types in cutaneous warts in general population. Warts infected with HPV 1 have a distinct clinical profile.